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KH7

Name: KH7
Brand: TargetMol
SKU: T15658
Price: 265 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15658Cas No. 330676-02-3

KH7 is a soluble inhibitor of adenylyl cyclase (sAC)-specific. It has IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibitor.

KH7

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Purity: 98.43%

Catalog No. T15658Cas No. 330676-02-3

Pack Size	Price	Availability
1 mg	$37	In Stock
2 mg	$50	In Stock
5 mg	$82	In Stock
10 mg	$132	In Stock
25 mg	$265	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$91	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:98.43%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	KH7 is a soluble inhibitor of adenylyl cyclase (sAC)-specific. It has IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibitor.
Targets&IC50	sAC:3-10 μM
In vitro	KH7 prevents the generation of CaSF. KH7 (10 μM) blocks this capacitation-induced cAMP increase. At higher concentrations (50 μM), 5- to 10-fold above its IC50 but still selective for sAC relative to tmACs, KH7 resulted in a significant decrease in the basal cAMP accumulation in sperm regardless of the incubation medium. The myocytes exert a negative inotropic effect (NIE) of approximately 20%, in the presence of KH7. This suggesting that sAC is involved in the normal generation of basal cardiac contractility [1,2].

Chemical Properties

Molecular Weight	419.3
Formula	C₁₇H₁₅BrN₄O₂S
Cas No.	330676-02-3
Smiles	CC(Sc1nc2ccccc2[nH]1)C(=O)N\N=C\c1cc(Br)ccc1O
Relative Density.	1.61 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 0.1 mg/mL (insoluble)

DMSO: 100 mg/mL (238.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3849 mL	11.9246 mL	23.8493 mL	119.2464 mL
5 mM	0.4770 mL	2.3849 mL	4.7699 mL	23.8493 mL
10 mM	0.2385 mL	1.1925 mL	2.3849 mL	11.9246 mL
20 mM	0.1192 mL	0.5962 mL	1.1925 mL	5.9623 mL
50 mM	0.0477 mL	0.2385 mL	0.4770 mL	2.3849 mL
100 mM	0.0238 mL	0.1192 mL	0.2385 mL	1.1925 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc