Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Mps1-IN-5 is a potent, orally active Mps1 inhibitor exhibiting an IC50 of 29 nM, known for triggering apoptosis and G2/M phase cell cycle arrest. This compound demonstrates antiproliferative and anti-tumor effects by inhibiting Mps1 phosphorylation and inducing DNA damage [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Mps1-IN-5 is a potent, orally active Mps1 inhibitor exhibiting an IC50 of 29 nM, known for triggering apoptosis and G2/M phase cell cycle arrest. This compound demonstrates antiproliferative and anti-tumor effects by inhibiting Mps1 phosphorylation and inducing DNA damage [1]. |
In vitro | Mps1-IN-5 (compound 12) inhibited the proliferation of MCF-7 and 4T1 cells in a time-dependent manner at concentrations ranging from 0-10 µM over 24, 48, and 72 hours [1]. Additionally, Mps1-IN-5 induced apoptosis and caused cell cycle arrest at the G2/M phase in MCF-7 and 4T1 cells in a dose-dependent fashion when applied at concentrations of 0, 0.5, 1.0, or 5.0 µM for 24 and 48 hours [1]. At concentrations of 0, 0.03, 0.1, 1, or 3 µM for 2 hours, the compound inhibited the phosphorylation of Mps1 and induced DNA damage [1]. |
In vivo | Mps1-IN-5 (30, 60 mg/kg; oral administration; daily for 15 days) suppresses tumor growth in a breast cancer model without significant toxicity [1]. |
Molecular Weight | 439.52 |
Formula | C24H25N9 |
CAS No. | 2890819-31-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Mps1-IN-5 2890819-31-3 inhibitor inhibit