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Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)

Catalog No. T36627 CAS 1234494-75-7

Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C)) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4).1,2LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used at a concentration of 10 μM.1It increases the level of H3K4 methylation, including H3K4me1 and H3K4me2 but not H3K9me2 levels, in HCT116 human colon carcinoma cells.2LSD inhibitor (1C) also induces re-expression of the Wnt signaling pathway proteins secreted frizzle-related protein 1 (SFRP1), SFRP4, and SFRP5, as well as the transcription factor GATA5, which are aberrantly silenced in HCT116 cells.

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Lysine-specific Demethylase Inhibitor (1C) (hydrochloride) Chemical Structure

Lysine-specific Demethylase Inhibitor (1C) (hydrochloride), CAS 1234494-75-7

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1 mg	Inquiry	$ 52.00
5 mg	Inquiry	$ 151.00
10 mg	Inquiry	$ 250.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	474.34
Formula	C15H40Cl4N8
CAS No.	1234494-75-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

H2O: 50 mg/mL

References and Literature

1. Sharma, S.K., Wu, Y., Steinbergs, N., et al.(Bis)urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulatorsJ. Med. Chem.53(14)5197-5212(2010) 2. Huang, Y., Greene, E., Murray Stewart, T., et al.Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genesProc. Natl. Acad. Sci. U.S.A.104(19)8023-8028(2007)

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Lysine-specific Demethylase Inhibitor (1C) (hydrochloride) 1234494-75-7 Lysine-specific Demethylase Inhibitor (1C) Lysinespecific Demethylase Inhibitor (1C) (hydrochloride) Lysine specific Demethylase Inhibitor (1C) (hydrochloride) inhibitor inhibit

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