Shopping Cart
- Remove All
- Your shopping cart is currently empty
Anti-COMP Polyclonal Antibody is a Rabbit antibody targeting COMP. Anti-COMP Polyclonal Antibody can be used in WB.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $220 | 7-10 days | |
100 μL | $374 | 7-10 days | |
200 μL | $528 | 7-10 days |
Description | Anti-COMP Polyclonal Antibody is a Rabbit antibody targeting COMP. Anti-COMP Polyclonal Antibody can be used in WB. |
Synonyms | THBS5, PSACH, MED, EPD1, EDM1, cartilage oligomeric matrix protein |
Ig Type | IgG |
Reactivity | Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Sheep) |
Verified Activity | Protein: Raji lysate; Primary: rabbit Anti-COMP (TMAB-00465) at 1:300; Secondary: HRP conjugated Goat-Anti-rabbit Igg (secondary antibody) at 1: 5000; Predicted band size: 83 kDa Observed band size: 77 kDa |
Application | |
Recommended Dose | WB: 1:500-2000 |
Antibody Type | Polyclonal |
Host Species | Rabbit |
Subcellular Localization | Secreted, extracellular space, extracellular matrix. |
Tissue Specificity | Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect. |
Construction | Polyclonal Antibody |
Purification | Protein A purified |
Appearance | Liquid |
Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Concentration | 1 mg/mL |
Research Background | The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2008]. |
Immunogen | KLH conjugated synthetic peptide: human COMP |
Antigen Species | Human |
Gene Name | COMP |
Gene ID | |
Protein Name | Cartilage oligomeric matrix protein |
Uniprot ID | |
Function | May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7. |
Molecular Weight | Theoretical: 83 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.