Myeloid Cell CD Proteins

Myeloid cells include dendritic cells, monocytes, macrophages, and granulocytes. A dendritic cell (DC) is an antigen-presenting cell of the mammalian immune system. A DC's main function is to process antigen material and present it on the cell surface to the T cells of the immune system. Monocytes are derived from myeloid progenitor cells in the bone marrow. There are three distinct subpopulations of human monocytes: classical, intermediate, and non-classical. Human peripheral blood mononuclear cells are defined based on the expression of cell surface antigens (CD14, CD16, and CD64) and chemokine receptors (CD192 (CCR2) and CX3CR1). Monocytes express leukocyte adhesion molecule (CD226), and the interaction between CD antigen and CD155 regulates monocyte migration. Monocytes play a key role in clearing invading bacteria, viruses, fungi and protozoa, and negatively affect the pathogenesis of inflammatory and degenerative diseases. Macrophages are a type of white blood cell of the innate immune system that engulf and digest pathogens, such as cancer cells, microbes, cellular debris, and foreign substances.They can be identified by their specific expression of proteins such as CD14, CD40, CD11b, CD64, F4/80 (mice)/EMR1 (human), lysozyme M, MAC-1/MAC-3 and CD68.