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Anti-PD-L1 Polyclonal Antibody 3
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Catalog No. TMAB-01361
Alias Pdl1, Pdcd1lg1, Pdcd1l1, CD274 molecule, B7h1, A530045L16Rik
Anti-PD-L1 Polyclonal Antibody 3 is a Rabbit antibody targeting PD-L1. Anti-PD-L1 Polyclonal Antibody 3 can be used in WB.
Anti-PD-L1 Polyclonal Antibody 3
Anti-PD-L1 Polyclonal Antibody 3
😃Good
Catalog No. TMAB-01361Alias Pdl1, Pdcd1lg1, Pdcd1l1, CD274 molecule, B7h1, A530045L16Rik
Anti-PD-L1 Polyclonal Antibody 3 is a Rabbit antibody targeting PD-L1. Anti-PD-L1 Polyclonal Antibody 3 can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $220 | 7-10 days | |
| 100 μL | $372 | 7-10 days | |
| 200 μL | $529 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-PD-L1 Polyclonal Antibody 3 is a Rabbit antibody targeting PD-L1. Anti-PD-L1 Polyclonal Antibody 3 can be used in WB. |
| Synonyms | Pdl1, Pdcd1lg1, Pdcd1l1, CD274 molecule, B7h1, A530045L16Rik |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat (predicted:Pig,Cow,Horse,Sheep) |
| Verified Activity | Sample: LOVO (Human) Cell Lysate at 30 μg Heart (Mouse) Lysate at 40 μg Kidney (Mouse) Lysate at 40 μg Muscle (Mouse) Lysate at 40 μg Heart (Rat) Lysate at 40 μg Muscle (Rat) Lysate at 40 μg Primary: Anti-PD-L1 (TMAB-01361) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 50 kDa Observed band size: 53 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Endomembrane system; Single-pass type I membrane protein. |
| Tissue Specificity | Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
| Immunogen | KLH conjugated synthetic peptide: human B7-H1/PDL1/CD274 |
| Antigen Species | Human |
| Gene Name | CD274 |
| Gene ID | |
| Protein Name | Programmed cell death 1 ligand 1 |
| Uniprot ID | |
| Biology Area | Tumor antigens,Tumor-associated antigens,Non-lineage,Autoimmune,pd-l1 |
| Function | Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. |
| Molecular Weight | Theoretical: 32 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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