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(2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid
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Catalog No. TN7074Cas No. 38489-76-8
(2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid displays EC50 values of 73.5 μM against T. cruzi. trypomastigotes.
(2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid
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Purity: 99.87%
Catalog No. TN7074Cas No. 38489-76-8
(2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid displays EC50 values of 73.5 μM against T. cruzi. trypomastigotes.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $75 | In Stock | In Stock | |
| 5 mg | $183 | In Stock | In Stock | |
| 10 mg | $288 | In Stock | In Stock | |
| 25 mg | $489 | In Stock | - | |
| 50 mg | Preferential | In Stock | - | |
| 1 mL x 10 mM (in DMSO) | $146 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.87%
Appearance:Solid
Color:White
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Product Introduction
(2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid AI Summary
(2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid exhibits a diverse range of bioactivities. It shows antioxidant activity, demonstrated by a deltaA value of 0.19 in the MTT assay. The compound displaces [3H]nicotinic acid from the human GPR109a receptor with a bioactivity of 7.0% at 10 µM. As a potent inhibitor of Human Flap endonuclease 1 (FEN1), (2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid has a potency of 31622.8 nM. It also shows antiviral activities against Influenza A virus (H1N1) by inhibiting the cytopathic effect and neuraminidase activity with EC50 and IC50 values greater than 100,000.0 nM, respectively.
When tested against the Gloeobacter violaceus ligand-gated ion channel, the compound significantly inhibits MES buffer pH 5.5-induced currents with 79.7% inhibition at 100 µM and demonstrates antagonist activity with an IC50 of 28800.0 nM. Furthermore, it possesses antibacterial activity against Mycobacterium tuberculosis H37Rv with an MIC of 312000.0 nM and displays cytotoxicity against mouse RAW264.7 cells with a GI50 of 2774000.0 nM, achieving a Selectivity Index of 8.8.
For Hepatitis B virus, it inhibits the secretion of HBeAg and HBsAg in human HepG2.2.15 cells with IC50 values of 526250.0 nM and 433150.0 nM, respectively, showing cytotoxicity with a CC50 of 503460.0 nM. The selectivity indexes for HBeAg and HBsAg inhibition are 0.96 and 1.16, respectively. The compound demonstrates antiviral activity against wild type HIV1 NL4-3 in human MT4 cells with an IC50 greater than 90000.0 nM, with a cytotoxic CC50 value also greater than 90000.0 nM.
However, (2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid shows no significant inhibition of the ATPase activity of His6-tagged p97 in Escherichia coli BL21 (DE3), nor does it affect the proteasomal turnover in human HeLa cells, with IC50 values exceeding 30,000 nM in these assays..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid displays EC50 values of 73.5 μM against T. cruzi. trypomastigotes. |
| Targets&IC50 | T. cruzi:73.5 μM(EC50) |
| Molecular Weight | 192.17 |
| Formula | C10H8O4 |
| Cas No. | 38489-76-8 |
| Smiles | OC(=O)\C=C\C1=CC2=C(OCO2)C=C1 |
| Relative Density. | 1.31g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (260.19 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 1.67 mg/mL (8.69 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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