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Anti-Phospho-FOXO1/3/4 (Thr24/32) Polyclonal Antibody
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Catalog No. TMAC-01541
Anti-Phospho-FOXO1/3/4 (Thr24/32) Polyclonal Antibody is a Rabbit antibody targeting Phospho-FOXO1/3/4 (Thr24/32). Anti-Phospho-FOXO1/3/4 (Thr24/32) Polyclonal Antibody can be used in WB.
Anti-Phospho-FOXO1/3/4 (Thr24/32) Polyclonal Antibody
Anti-Phospho-FOXO1/3/4 (Thr24/32) Polyclonal Antibody
😃Good
Catalog No. TMAC-01541
Anti-Phospho-FOXO1/3/4 (Thr24/32) Polyclonal Antibody is a Rabbit antibody targeting Phospho-FOXO1/3/4 (Thr24/32). Anti-Phospho-FOXO1/3/4 (Thr24/32) Polyclonal Antibody can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $217 | 7-10 days | |
| 100 μL | $316 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-Phospho-FOXO1/3/4 (Thr24/32) Polyclonal Antibody is a Rabbit antibody targeting Phospho-FOXO1/3/4 (Thr24/32). Anti-Phospho-FOXO1/3/4 (Thr24/32) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human,Mouse |
| Application | |
| Recommended Dose | WB: 1:500-1000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Appearance | Liquid |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts syngernistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A to activate the expression of genes such as IGFBP1, G6PC and PPCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | Peptide sequence around phosphorylation site of threonine 24/32(S-C-T(p)-W-P) derived from Human FOXO1/3/4-pan |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 78 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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