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NDI-034858

Catalog No. T62902 CAS 2272904-53-5

Synonyms: TAK-279, NDI-03485

NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23.

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NDI-034858, CAS 2272904-53-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 263.00
5 mg	In stock	$ 788.00
10 mg	In stock	$ 1,260.00
25 mg	In stock	$ 1,870.00
50 mg	In stock	$ 2,530.00
100 mg	In stock	$ 3,390.00

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Purity: 100%

ee: 100%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23.
In vitro	NDI-034858 (compound I-908) (10 μM) demonstrates inhibitory activity against Tyk2 and JAK enzymes. It achieves this by targeting the Tyk2 JH1 domain and the JAK JH1 domain, resulting in inhibition rates of less than 50% for both enzymes.[2]

Synonyms	TAK-279, NDI-03485
Molecular Weight	460.49
Formula	C23H24N8O3
CAS No.	2272904-53-5

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45.0 mg/mL (97.7 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Leit S, et al. Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279. J Med Chem. 2023;66(15):10473-10496. 2. Masse, et al. Pyrazolopyrimidines as TYK2 inhibitors and their preparation: World Intellectual Property Organization, WO2019023468. 3. Deng L, et al. Recent progress on tyrosine kinase 2 JH2 inhibitors. Int Immunopharmacol. 2023;121:110434. 4. Nielsen OH, et al. Selective tyrosine kinase 2 inhibitors in inflammatory bowel disease. Trends Pharmacol Sci. 2022;43(5):424-436.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Clinical Compound Library Inhibitor Library

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Keywords

NDI-034858 2272904-53-5 Immunology/Inflammation Tyrosine Kinase/Adaptors Tyrosine Kinases IL Receptor NDI03485 NDI 034858 TAK279 TAK 279 TAK-279 NDI 03485 NDI034858 NDI-03485 inhibitor inhibit

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