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NDI-034858 (Synonyms: TAK-279)

Name: NDI-034858
Brand: TargetMol
SKU: T62902
Price: 263 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T62902 Copy Product Info

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NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23.

NDI-034858

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Catalog No. T62902

Synonyms TAK-279

Cas No. 2272904-53-5

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Pack Size	Price	USA Stock	Global Stock
1 mg	$263	In Stock	In Stock
5 mg	$788	In Stock	In Stock
10 mg	$1,260	In Stock	In Stock
25 mg	$1,870	In Stock	In Stock
50 mg	$2,530	In Stock	In Stock
100 mg	$3,390	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:>99.99%

ee:100%

Appearance:Solid

Color:White

Resource Download

COA HPLC CSFC HNMR

Product Introduction

Bioactivity

Description	NDI-034858 (TAK-279) is a tyrosine kinase 2 (TYK2) inhibitor (Kd<200 pM) that targets the JH2 structural domain of Tyk2 for the treatment of autoimmune diseases caused by aberrant expression of IL12 and IL23.
In vitro	NDI-034858 (compound I-908) (10 μM) demonstrates inhibitory activity against Tyk2 and JAK enzymes. It achieves this by targeting the Tyk2 JH1 domain and the JAK JH1 domain, resulting in inhibition rates of less than 50% for both enzymes.[2]
Synonyms	TAK-279

Chemical Properties

Molecular Weight	460.49
Formula	C₂₃H₂₄N₈O₃
Cas No.	2272904-53-5
Smiles	CNc1cc(Nc2cccn(-c3ccccn3)c2=O)nc2c(cnn12)C(=O)N[C@@H]1CC[C@H]1OC

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (97.72 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1716 mL	10.8580 mL	21.7160 mL	108.5800 mL
5 mM	0.4343 mL	2.1716 mL	4.3432 mL	21.7160 mL
10 mM	0.2172 mL	1.0858 mL	2.1716 mL	10.8580 mL
20 mM	0.1086 mL	0.5429 mL	1.0858 mL	5.4290 mL
50 mM	0.0434 mL	0.2172 mL	0.4343 mL	2.1716 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc