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PGlu-3-methyl-His-Pro-NH2 TFA

Name: PGlu-3-methyl-His-Pro-NH2 TFA
Brand: TargetMol
SKU: T19511
Rating: 4.5 (1 reviews)

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Catalog No. T19511

Alias A-42872 TFA

PGlu-3-methyl-His-Pro-NH2 TFA enhances binding to pituitary TRH receptors, thereby increasing the stimulation of thyroid-stimulating hormone (TSH) release from the pituitary.

PGlu-3-methyl-His-Pro-NH2 TFA

Copy Product Info

😃Good

Catalog No. T19511Alias A-42872 TFA

PGlu-3-methyl-His-Pro-NH2 TFA enhances binding to pituitary TRH receptors, thereby increasing the stimulation of thyroid-stimulating hormone (TSH) release from the pituitary.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	PGlu-3-methyl-His-Pro-NH2 TFA enhances binding to pituitary TRH receptors, thereby increasing the stimulation of thyroid-stimulating hormone (TSH) release from the pituitary.
In vitro	PGlu-3-methyl-His-Pro-NH2 TFA demonstrates greater potency in inducing behavioral effects and in stimulating the release of growth hormone and thyroid-stimulating hormone [1].
Synonyms	A-42872 TFA

Chemical Properties

Molecular Weight	490.43
Formula	C₁₉H₂₅F₃N₆O₆
Smiles	CN1C(C[C@H](NC([C@@H](N2)CCC2=O)=O)C(N3[C@@H](CCC3)C(N)=O)=O)=CN=C1.OC(C(F)(F)F)=O
Relative Density.	no data available
Sequence	H-DL-Pyr-DL-His-DL-Pro-OH
Sequence Short	XHP

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 250 mg/mL (509.76 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.0390 mL	10.1951 mL	20.3903 mL	101.9513 mL
5 mM	0.4078 mL	2.0390 mL	4.0781 mL	20.3903 mL
10 mM	0.2039 mL	1.0195 mL	2.0390 mL	10.1951 mL
20 mM	0.1020 mL	0.5098 mL	1.0195 mL	5.0976 mL
50 mM	0.0408 mL	0.2039 mL	0.4078 mL	2.0390 mL
100 mM	0.0204 mL	0.1020 mL	0.2039 mL	1.0195 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc