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PGlu-3-methyl-His-Pro-NH2 TFA

Name: PGlu-3-methyl-His-Pro-NH2 TFA
Brand: TargetMol
SKU: T19511
Rating: 4.5 (1 reviews)

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Catalog No. T19511

Alias A-42872 TFA

PGlu-3-methyl-His-Pro-NH2 TFA enhances binding to pituitary TRH receptors, thereby increasing the stimulation of thyroid-stimulating hormone (TSH) release from the pituitary.

PGlu-3-methyl-His-Pro-NH2 TFA

😃Good

Catalog No. T19511Alias A-42872 TFA

PGlu-3-methyl-His-Pro-NH2 TFA enhances binding to pituitary TRH receptors, thereby increasing the stimulation of thyroid-stimulating hormone (TSH) release from the pituitary.

Pack Size	Price	Availability
25 mg	$1,520	6-8 weeks
50 mg	$1,980	6-8 weeks
100 mg	$2,500	6-8 weeks

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Product Introduction

Bioactivity

Description	PGlu-3-methyl-His-Pro-NH2 TFA enhances binding to pituitary TRH receptors, thereby increasing the stimulation of thyroid-stimulating hormone (TSH) release from the pituitary.
In vitro	PGlu-3-methyl-His-Pro-NH2 TFA demonstrates greater potency in inducing behavioral effects and in stimulating the release of growth hormone and thyroid-stimulating hormone [1].
Synonyms	A-42872 TFA

Chemical Properties

Molecular Weight	490.43
Formula	C₁₉H₂₅F₃N₆O₆
Relative Density.	no data available
Sequence	H-DL-Pyr-DL-His-DL-Pro-OH
Sequence Short	XHP

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 250 mg/mL (509.76 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.0390 mL	10.1951 mL	20.3903 mL	101.9513 mL
5 mM	0.4078 mL	2.0390 mL	4.0781 mL	20.3903 mL
10 mM	0.2039 mL	1.0195 mL	2.0390 mL	10.1951 mL
20 mM	0.1020 mL	0.5098 mL	1.0195 mL	5.0976 mL
50 mM	0.0408 mL	0.2039 mL	0.4078 mL	2.0390 mL
100 mM	0.0204 mL	0.1020 mL	0.2039 mL	1.0195 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc