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SM-102
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Catalog No. T9410Cas No. 2089251-47-6
SM-102 is the only ionizable amino cationic lipid currently clinically approved for RNA therapeutics and can be used to synthesize lipid nanoparticles (LNPs). It shows potential in the development of LNPs for the delivery of mRNA-based vaccines.
SM-102
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Purity: 99.74%
Catalog No. T9410Cas No. 2089251-47-6
SM-102 is the only ionizable amino cationic lipid currently clinically approved for RNA therapeutics and can be used to synthesize lipid nanoparticles (LNPs). It shows potential in the development of LNPs for the delivery of mRNA-based vaccines.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | In Stock | In Stock | |
| 5 mg | $42 | In Stock | In Stock | |
| 10 mg | $67 | In Stock | In Stock | |
| 25 mg | $136 | In Stock | In Stock | |
| 50 mg | $219 | In Stock | In Stock | |
| 100 mg | $353 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $65 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.74%
Color:Transparent to Orange
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SM-102 is the only ionizable amino cationic lipid currently clinically approved for RNA therapeutics and can be used to synthesize lipid nanoparticles (LNPs). It shows potential in the development of LNPs for the delivery of mRNA-based vaccines. |
| Targets&IC50 | IK (erg):108 μM, IK (erg) (MA-10 cells):98 μM |
| In vitro | METHODS: The effects of SM-102 on ionic currents in two endocrine cells, rat pituitary tumor (GH3) cells and mouse Leydig tumor (MA-10) cells, or microglial cells (BV2), were investigated. Hyperpolarization-activated K currents in these cells bathed in a high-K, Ca2+-free extracellular solution were examined to assess the effects of SM-102 on the amplitude and hysteresis of erg-mediated K currents (I+K(erg)). RESULTS The addition of SM-102 effectively blocked IK(erg) in a concentration-dependent manner with a half-peak concentration (IC50) of 108 μM, which was similar to the KD value required for its enhanced current inactivation time constant (i.e., 134 μM); in the presence of SM-102, exposure of cells to the transfection reagent TurboFectinTM 8.0 (0.1%, v/v) was able to effectively inhibit hyperpolarization-activated IK(erg) and increase the inactivation time course of the current; in addition, in GH3 cells dialyzed with spermine (30 μM), the amplitude of IK(erg) gradually decreased; further use of SM-102 (100 μM) or TurboFectin (0.1%) further reduced the current amplitude; in MA-10 Leydig cells, the IC50 value of SM-102-induced IK(erg) inhibition in MA-10 cells was 98 μM. In BV2 microglia, the amplitude of inwardly rectifying K currents is inhibited by SM-102.[3] |
| Molecular Weight | 710.17 |
| Formula | C44H87NO5 |
| Cas No. | 2089251-47-6 |
| Smiles | CCCCCCCCCCCOC(=O)CCCCCN(CCO)CCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC |
| Relative Density. | 0.925 g/cm3 (Predicted) |
| Storage | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (77.45 mM), Sonication is recommended.  Ethanol: 100 mg/mL (140.81 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.82 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
Ethanol
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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