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YH239-EE

🥰Excellent

Catalog No. T6149Cas No. 1364488-67-4

YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.

YH239-EE

🥰Excellent

Purity: 99.61%

Catalog No. T6149Cas No. 1364488-67-4

YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$60	In Stock	In Stock
10 mg	$96	In Stock	In Stock
25 mg	$198	In Stock	In Stock
50 mg	$369	In Stock	In Stock
100 mg	$549	In Stock	-
1 mL x 10 mM (in DMSO)	$100	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.61%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
In vitro	YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). [1]
Cell Research	Cell lines are harvested in log-phase growth and seeded following exposure to p53-MDM2 antagonists. Cell number and viability are determined by staining cells with Trypan blue 0.4% and counted with Countess slides.(Only for Reference)

Chemical Properties

Molecular Weight	504.41
Formula	C₂₅H₂₇Cl₂N₃O₄
Cas No.	1364488-67-4
Smiles	CCOC(=O)c1[nH]c2cc(Cl)ccc2c1C(N(Cc1ccc(Cl)cc1)C=O)C(=O)NC(C)(C)C
Relative Density.	1.313 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 15 mg/mL (29.74 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (184.37 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9825 mL	9.9126 mL	19.8251 mL	99.1257 mL
5 mM	0.3965 mL	1.9825 mL	3.9650 mL	19.8251 mL
10 mM	0.1983 mL	0.9913 mL	1.9825 mL	9.9126 mL
20 mM	0.0991 mL	0.4956 mL	0.9913 mL	4.9563 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0397 mL	0.1983 mL	0.3965 mL	1.9825 mL
100 mM	0.0198 mL	0.0991 mL	0.1983 mL	0.9913 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

YH239-EE

YH239-EE

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