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TRPC3/6-IN-1
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Catalog No. T61407Cas No. 736945-96-3
TRPC3/6-IN-1 is a highly potent and selective inhibitor that blocks the activity of canonical transient receptor channels TRPC3 and TRPC6, showing significant potency against human isoforms hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. This compound is valuable for research on chronic models of heart failure [1].
TRPC3/6-IN-1
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Catalog No. T61407Cas No. 736945-96-3
TRPC3/6-IN-1 is a highly potent and selective inhibitor that blocks the activity of canonical transient receptor channels TRPC3 and TRPC6, showing significant potency against human isoforms hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. This compound is valuable for research on chronic models of heart failure [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $120 | 35 days | 35 days | |
| 5 mg | $388 | 35 days | 35 days | |
| 10 mg | $652 | 35 days | 35 days | |
| 25 mg | $1,330 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | TRPC3/6-IN-1 is a highly potent and selective inhibitor that blocks the activity of canonical transient receptor channels TRPC3 and TRPC6, showing significant potency against human isoforms hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. This compound is valuable for research on chronic models of heart failure [1]. |
| Targets&IC50 | TRPC3 (human):1260 nM, TRPC6 (human):500 nM |
| In vitro | TRPC3/6-IN-1 exhibits blocking activity against hTRPC3 and hTRPC6, achieving half-maximal inhibitory concentrations (IC50) of 1260 nM and 500 nM, respectively [1]. |
| In vivo | TRPC3/6-IN-1 (compound 3) exhibits favorable pharmacokinetics in rats. At an intravenous dose of 0.93 mg/kg, it reaches a Cmax of 250 ng/ml with a clearance rate of 120 ml/min/kg. The MRT is 0.3 hours and the DNAUC is 0.14 h kg/L, indicating an oral bioavailability (~F) of approximately 1%. |
| Molecular Weight | 365.45 |
| Formula | C20H19N3O2S |
| Cas No. | 736945-96-3 |
| Smiles | C(=O)(N1CC=2C(CC1)=CC=CC2)C=3N=C(NC4=CC=C(OC)C=C4)SC3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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