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CGP-20712

Name: CGP-20712
Brand: TargetMol
SKU: T30846
Price: 350 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T30846Cas No. 137888-49-4

Alias UNII-SIO2UEZ19H, CGP 20712

CGP-20712 is a selective β 1-adrenoceptor antagonist with an IC50 of 0.7 nM.

CGP-20712

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Purity: 99.58%

Catalog No. T30846Alias UNII-SIO2UEZ19H, CGP 20712Cas No. 137888-49-4

CGP-20712 is a selective β 1-adrenoceptor antagonist with an IC50 of 0.7 nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$350	In Stock	In Stock
5 mg	$828	In Stock	In Stock
10 mg	$1,130	In Stock	In Stock
25 mg	$1,590	In Stock	In Stock
50 mg	$1,980	In Stock	In Stock
100 mg	$2,500	In Stock	In Stock
500 mg	$4,900	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.58%

Appearance:Solid

Color:White to Yellow

Resource Download

COA FNMR HNMR LCMS

Product Introduction

Bioactivity

Description	CGP-20712 is a selective β 1-adrenoceptor antagonist with an IC50 of 0.7 nM.
Targets&IC50	β1-adrenoceptor:0.7 nM, β2-adrenoceptor:6700 nM
In vitro	In brown adipocytes, CGP-20712 (1 μM) significantly inhibited UCP1 gene expression induced by NE. However, CGP-20712 had no effect on lipolysis. These results suggested that β1-adrenoceptor mediated UCP1 gene expression.[4] In neocortical membranes, CGP 20712 exhibited affinity for β1-adrenoceptor and β2-adrenoceptor with IC50 values of 0.7 and 6700 nM, respectively.[1]
In vivo	CGP 20712 (a selective beta 1-adrenergic receptor antagonist) (5 mg/kg; Pretreatment of 8-day-old rats) did not change the plasma ACTH response to insulin injection.[3]
Synonyms	UNII-SIO2UEZ19H, CGP 20712

Chemical Properties

Molecular Weight	494.46
Formula	C₂₃H₂₅F₃N₄O₅
Cas No.	137888-49-4
Smiles	CN1C(=NC(C(F)(F)F)=C1)C2=CC=C(OCC(CNCCOC3=CC(C(N)=O)=C(O)C=C3)O)C=C2
Relative Density.	1.40 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (91.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0224 mL	10.1120 mL	20.2241 mL	101.1204 mL
5 mM	0.4045 mL	2.0224 mL	4.0448 mL	20.2241 mL
10 mM	0.2022 mL	1.0112 mL	2.0224 mL	10.1120 mL
20 mM	0.1011 mL	0.5056 mL	1.0112 mL	5.0560 mL
50 mM	0.0404 mL	0.2022 mL	0.4045 mL	2.0224 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc