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PF 05089771

Name: PF 05089771
Brand: TargetMol
SKU: T7502L
Price: 326 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T7502LCas No. 1235403-62-9

Alias PF-05089771, PF05089771

PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent.

PF 05089771

🥰Excellent

Purity: 99.42%

Catalog No. T7502LAlias PF-05089771, PF05089771Cas No. 1235403-62-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$62	In Stock	In Stock
5 mg	$148	In Stock	In Stock
10 mg	$196	In Stock	In Stock
25 mg	$326	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$167	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.42%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent.
Targets&IC50	CynNav1.7:12 nM (IC50), Nav1.7 (dog):13 nM (IC50), Nav1.7 (human):11 nM (IC50), Nav1.7 (mouse):8 nM (IC50), Nav1.7 (rat):171 nM (IC50)
Synonyms	PF-05089771, PF05089771

Chemical Properties

Molecular Weight	500.35
Formula	C₁₈H₁₂Cl₂FN₅O₃S₂
Cas No.	1235403-62-9
Smiles	Nc1n[nH]cc1-c1cc(Cl)ccc1Oc1cc(F)c(cc1Cl)S(=O)(=O)Nc1cscn1
Relative Density.	1.673 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (59.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9986 mL	9.9930 mL	19.9860 mL	99.9300 mL
5 mM	0.3997 mL	1.9986 mL	3.9972 mL	19.9860 mL
10 mM	0.1999 mL	0.9993 mL	1.9986 mL	9.9930 mL
20 mM	0.0999 mL	0.4997 mL	0.9993 mL	4.9965 mL
50 mM	0.0400 mL	0.1999 mL	0.3997 mL	1.9986 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc