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187-1, N-WASP inhibitor

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Catalog No. TP1977Cas No. 380488-27-7

Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization.

187-1, N-WASP inhibitor

187-1, N-WASP inhibitor

😃Good
Catalog No. TP1977Cas No. 380488-27-7
Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization.
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Product Introduction

Bioactivity
Description
Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization.
Chemical Properties
Molecular Weight1784.13
FormulaC96H122N18O16
Cas No.380488-27-7
Relative Density.no data available
SequenceCyclo[Gln-Lys-{d-Phe}-{d-Pro}-{d-Phe}-Phe-{d-Pro}-Gln-Lys-{d-Phe}-{d-Pro}-{d-Phe}-Phe-{d-Pro}]
Sequence ShortCyclo[QK-{d-Phe}-{d-Pro}-{d-Phe}-F-{d-Pro}-QK-{d-Phe}-{d-Pro}-{d-Phe}-F-{d-Pro}]
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 2 mg/mL (1.12 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.5605 mL2.8025 mL5.6050 mL28.0249 mL

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Keywords

187 1, N WASP inhibitor187-1, N-WASP inhibitor1871, NWASP inhibitor
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