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VGX-1027

Name: VGX-1027
Brand: TargetMol
SKU: T1813
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1813Cas No. 6501-72-0

Alias VGX1027, VGX 1027, GIT 27

VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.

VGX-1027

🥰Excellent

Purity: 99.86%

Catalog No. T1813Alias VGX1027, VGX 1027, GIT 27Cas No. 6501-72-0

VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.

Pack Size	Price	Availability
5 mg	$42	In Stock
10 mg	$68	In Stock
25 mg	$142	In Stock
50 mg	$229	In Stock
100 mg	$367	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock

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Batch Information

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Purity:99.86%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.
In vitro	VGX-1027 enhances survival rates and ameliorates clinical and histopathological signs in the NZB/NZW F1 model of systemic lupus erythematosus, thereby improving disease progression. It prevents the spontaneous development of Type 1 diabetes in NOD mice and counters the acceleration of diabetes induced either by cyclophosphamide assault or by the adoptive transfer of diabetogenic spleen cells in NOD mice. Furthermore, VGX-1027 reduces clinical symptoms of diabetes induced by MLD-STZ and inhibits pathological histological changes in the pancreas.
In vivo	VGX-1027 exhibits inhibitory effects on the proliferation of gut bacterial antigen-reactive CD4+ CD25- T cells in vitro. It significantly suppresses the accumulation of TNF-α and nitrites induced by IL-1β/IFN-γ, and notably enhances cell survival by interfering with the toxic effects of cytokines.
Synonyms	VGX1027, VGX 1027, GIT 27

Chemical Properties

Molecular Weight	205.21
Formula	C₁₁H₁₁NO₃
Cas No.	6501-72-0
Smiles	OC(=O)CC1CC(=NO1)c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20.5 mg/mL (99.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8731 mL	24.3653 mL	48.7306 mL	243.6528 mL
5 mM	0.9746 mL	4.8731 mL	9.7461 mL	48.7306 mL
10 mM	0.4873 mL	2.4365 mL	4.8731 mL	24.3653 mL
20 mM	0.2437 mL	1.2183 mL	2.4365 mL	12.1826 mL
50 mM	0.0975 mL	0.4873 mL	0.9746 mL	4.8731 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc