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Prazosin

Name: Prazosin
Brand: TargetMol
SKU: T22406
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22406Cas No. 19216-56-9

Alias Prazosine, Prazocin, Furazosin

Prazosin (Prazosine), an α1-blocker, acts as an inverse agonist at alpha-1 adrenergic receptors and is used to treat hypertension.

Prazosin

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Purity: 99.86%

Catalog No. T22406Alias Prazosine, Prazocin, FurazosinCas No. 19216-56-9

Prazosin (Prazosine), an α1-blocker, acts as an inverse agonist at alpha-1 adrenergic receptors and is used to treat hypertension.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$42	In Stock	-
25 mg	$66	Inquiry	Inquiry
50 mg	$95	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Prazosin AI Summary

Prazosin exhibits strong alpha-1 adrenergic receptor antagonism with a very high binding affinity, demonstrated by Ki values ranging from 0.19 nM to 0.32 nM across different assays. It shows a significantly lower affinity for the alpha-2 adrenergic receptor, with Ki values up to 4830.0 nM. This compound is highly selective for alpha-1 receptors over alpha-2 receptors, indicated by a selectivity ratio of around 1258.9. Prazosin effectively reduces blood pressure in spontaneously hypertensive rats, showing dose-dependent antihypertensive activity with a maximum reduction of 45.0 mmHg at an oral dose of 30 mg/kg. It also exhibits significant vasorelaxant activity, blocking norepinephrine-induced contractions in rat and rabbit arterial tissues. Furthermore, Prazosin demonstrates robust antagonist activity in various adrenergic subtypes, notably alpha-1A, alpha-1B, and alpha-1D adrenergic receptors. Along with the cardiovascular functions, it also shows potential in modulating neurotransmitter responses, given its efficacy in displacing radioligands like [3H]prazosin from rat cerebral cortex membranes and displaying antagonist activity at the dopamine D2 receptors. Prazosin's effective oral bioavailability and selective inhibition properties make it a promising candidate for addressing cardiovascular conditions such as hypertension..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Prazosin (Prazosine), an α1-blocker, acts as an inverse agonist at alpha-1 adrenergic receptors and is used to treat hypertension.
Synonyms	Prazosine, Prazocin, Furazosin

Chemical Properties

Molecular Weight	383.4
Formula	C₁₉H₂₁N₅O₄
Cas No.	19216-56-9
Smiles	NC=1C2=C(N=C(N1)N3CCN(C(=O)C4=CC=CO4)CC3)C=C(OC)C(OC)=C2
Relative Density.	1.352g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (130.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6082 mL	13.0412 mL	26.0824 mL	130.4121 mL
5 mM	0.5216 mL	2.6082 mL	5.2165 mL	26.0824 mL
10 mM	0.2608 mL	1.3041 mL	2.6082 mL	13.0412 mL
20 mM	0.1304 mL	0.6521 mL	1.3041 mL	6.5206 mL
50 mM	0.0522 mL	0.2608 mL	0.5216 mL	2.6082 mL
100 mM	0.0261 mL	0.1304 mL	0.2608 mL	1.3041 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc