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Bekanamycin

Name: Bekanamycin
Brand: TargetMol
SKU: T8118
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8118Cas No. 4696-76-8

Alias Kanamycin B

Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic extracted from Streptomyces kanamyceticus, which inhibits a range of Gram-positive and Gram-negative bacteria.

Bekanamycin

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Purity: 99.97%

Catalog No. T8118Alias Kanamycin BCas No. 4696-76-8

Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic extracted from Streptomyces kanamyceticus, which inhibits a range of Gram-positive and Gram-negative bacteria.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$34	In Stock	In Stock
100 mg	$48	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Color:White

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Product Introduction

Bekanamycin AI Summary

Bekanamycin exhibits broad-spectrum antibacterial activity against various bacterial strains, including Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Klebsiella pneumoniae, Salmonella Typhimurium, Enterobacter cloacae, and Serratia marcescens. The compound shows potent activity with Minimum Inhibitory Concentrations (MIC) ranging from 0.39 to 3.125 ug/mL. Notably, it has MIC values of 0.39 ug/mL against Bacillus subtilis, 1.56 ug/mL against Staphylococcus aureus and Escherichia coli, and 3.13 ug/mL against Pseudomonas aeruginosa. Additionally, Bekanamycin demonstrates a binding affinity to various RNA constructs and the 16S ribosomal RNA A-site, suggesting potential mechanisms of action related to interference with bacterial protein synthesis and RNA binding. Furthermore, it shows moderate activity against lysosomal phospholipase A1 with an IC50 value of 110000.0 nM and inhibition metrics in various enzymatic and cellular assays. This combination of properties highlights Bekanamycin's potential as a robust antimicrobial agent targeting both Gram-positive and Gram-negative bacteria..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Bekanamycin (Kanamycin B) is an aminoglycoside antibiotic extracted from Streptomyces kanamyceticus, which inhibits a range of Gram-positive and Gram-negative bacteria.
Targets&IC50	HEK293 cells:> 500 μg/mL, NIH3T3 cells:139.6 μM
In vitro	METHODS: : HEK293 and NIH3T3 were treated with Bekanamycin for 24 hours, and the cell growth inhibition was detected by MTT assay. RESULTS: Bekanamycin did not inhibit the growth of HEK293, with an IC50> 500 μg/mL. Bekanamycin inhibited the growth of NIH3T3, with an IC50=139.6 μM. [1] [2]
Synonyms	Kanamycin B

Chemical Properties

Molecular Weight	483.51
Formula	C₁₈H₃₇N₅O₁₀
Cas No.	4696-76-8
Smiles	O([C@H]1[C@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](N)[C@H]2O)[C@H](N)C[C@@H]1N)[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3N
Relative Density.	1.59g/cm3

Storage & Solubility Information

Storage

store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 1 mg/mL (2.07 mM), Sonication and heating to 80℃ are recommended.

H2O: 247.5 mg/mL (511.88 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0682 mL	10.3410 mL	20.6821 mL	103.4105 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.4136 mL	2.0682 mL	4.1364 mL	20.6821 mL
10 mM	0.2068 mL	1.0341 mL	2.0682 mL	10.3410 mL
20 mM	0.1034 mL	0.5171 mL	1.0341 mL	5.1705 mL
50 mM	0.0414 mL	0.2068 mL	0.4136 mL	2.0682 mL
100 mM	0.0207 mL	0.1034 mL	0.2068 mL	1.0341 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc