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TH588

Name: TH588
Brand: TargetMol
SKU: T2037
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2037Cas No. 1609960-31-7

TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.

TH588

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Purity: 99.82%

Catalog No. T2037Cas No. 1609960-31-7

TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$35	In Stock	In Stock
5 mg	$57	In Stock	In Stock
10 mg	$83	In Stock	In Stock
25 mg	$128	In Stock	In Stock
50 mg	$218	In Stock	In Stock
100 mg	$410	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$63	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.
Targets&IC50	MTH1:5 nM
In vitro	In mice carrying xenografts with the BRAFV600E mutation, TH588 (30 mg/kg, subcutaneously) reduces tumor growth rates. Additionally, in mice bearing SW480 colon or MCF7 breast cancer xenografts, TH588 (30 mg/kg, subcutaneously) inhibits MTH1, resulting in decreased tumor growth.
In vivo	TH588 induces DNA damage in U2OS cells, triggering ATM-p53-mediated DNA repair and apoptotic responses. It exhibits selective cytotoxicity towards U2OS and other cancer cell lines while showing minimal toxicity towards several primary or immortalized cell lines.

Chemical Properties

Molecular Weight	295.17
Formula	C₁₃H₁₂Cl₂N₄
Cas No.	1609960-31-7
Smiles	Nc1nc(NC2CC2)cc(n1)-c1cccc(Cl)c1Cl
Relative Density.	1.505 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 88.33 mg/mL (299.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3879 mL	16.9394 mL	33.8788 mL	169.3939 mL
5 mM	0.6776 mL	3.3879 mL	6.7758 mL	33.8788 mL
10 mM	0.3388 mL	1.6939 mL	3.3879 mL	16.9394 mL
20 mM	0.1694 mL	0.8470 mL	1.6939 mL	8.4697 mL
50 mM	0.0678 mL	0.3388 mL	0.6776 mL	3.3879 mL
100 mM	0.0339 mL	0.1694 mL	0.3388 mL	1.6939 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc