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Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody

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Catalog No. TMAC-03418

Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Presenilin 1 (Ser357). Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA.

Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody

Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody

😃Good
Catalog No. TMAC-03418
Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Presenilin 1 (Ser357). Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA.
Pack SizePriceAvailabilityQuantity
50 μL$2177-10 days
100 μL$3177-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Presenilin 1 (Ser357). Anti-Phospho-Presenilin 1 (Ser357) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA.
Ig Type
IgG
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:500-2000; IHC-P: 1:100-300; ELISA: 1:5000
Antibody Type
Polyclonal
Host SpeciesRabbit
ConstructionPolyclonal Antibody
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
AppearanceLiquid
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Research Backgroundpresenilin 1(PSEN1) Homo sapiens Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008],
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
Phospho
Antigen Details
Immunogen
A synthesized phosphopeptide: human PSEN1 around the phosphorylation site of Ser357. AA range:323-372
Antigen Species
human
Uniprot ID
Chemical Properties
Molecular WeightActual: 43 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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