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HIF-1/2α-IN-2
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Catalog No. T61102 Copy Product Info
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HIF-1/2α-IN-2 is a selective inhibitor targeting hypoxia-inducible factors 1α and 2α (HIF-1α and HIF-2α). It induces a state of cellular iron deficiency by inhibiting the activity of iron-sulfur cluster assembly protein 2 (ISCA2), thereby reducing HIF-2α synthesis and ultimately triggering ferroptosis. HIF-1/2α-IN-2 is widely used in research related to tumor biology, metabolic regulation, and ischemia.
Cas No. 862974-22-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $63 | - | In Stock | |
| 5 mg | Preferential | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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| Description | HIF-1/2α-IN-2 is a selective inhibitor targeting hypoxia-inducible factors 1α and 2α (HIF-1α and HIF-2α). It induces a state of cellular iron deficiency by inhibiting the activity of iron-sulfur cluster assembly protein 2 (ISCA2), thereby reducing HIF-2α synthesis and ultimately triggering ferroptosis. HIF-1/2α-IN-2 is widely used in research related to tumor biology, metabolic regulation, and ischemia. |
| In vitro | HIF-1/2α-IN-2(0-25 μM; 24 h) decreases HIF-2α translation instead of transcription, with a downward trend in VEGFA and POU5F1 (HIF-2α target genes) transcription and insignificant effect on EPAS1 (HIF-2α)[1]. HIF-1/2α-IN-2 (0-100 μM, 24 h) inhibits the production of luciferase driven by the HIF-2α Iron-Responsive Element (IRE) luciferase reporter with an IC50 value of 3.9 μM, to block IRE-dependent translation of HIF-2α[1]. HIF-1/2α-IN-2 (0, 10, 50 μM) protects ISCA2 from Pronase-mediated (4 μg/mL) degradation, and (1.5 μM; 24 h) targets ISCA2 to induce iron and metals accumulation in normoxia 786-0 cells[1]. HIF-1/2α-IN-2 (0-100 μM; 24 h) results ISCA2 inhibition and promotes cell death via ferroptosis[1]. |
| Molecular Weight | 342.35 |
| Formula | C16H11FN4O2S |
| Cas No. | 862974-22-9 |
| Smiles | FC=1C=CC(=CC1)C2=NN=C(O2)NC3=NC=4C(OC)=CC=CC4S3 |
| Storage | Keep away from moisture,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: HIF-1/2α-IN-2 chemical structure | HIF-1/2α-IN-2 in vitro | HIF-1/2α-IN-2 formula | HIF-1/2α-IN-2 molecular weight
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