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Anti-Phospho-LIM Kinase 2 (Thr505) Polyclonal Antibody
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Catalog No. TMAB-10907
Anti-Phospho-LIM Kinase 2 (Thr505) Polyclonal Antibody is a Rabbit antibody targeting Phospho-LIM Kinase 2 (Thr505). Anti-Phospho-LIM Kinase 2 (Thr505) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-LIM Kinase 2 (Thr505) Polyclonal Antibody
Anti-Phospho-LIM Kinase 2 (Thr505) Polyclonal Antibody
😃Good
Catalog No. TMAB-10907
Anti-Phospho-LIM Kinase 2 (Thr505) Polyclonal Antibody is a Rabbit antibody targeting Phospho-LIM Kinase 2 (Thr505). Anti-Phospho-LIM Kinase 2 (Thr505) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-LIM Kinase 2 (Thr505) Polyclonal Antibody is a Rabbit antibody targeting Phospho-LIM Kinase 2 (Thr505). Anti-Phospho-LIM Kinase 2 (Thr505) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Rat (predicted:Human,Mouse,Chicken,Dog,Pig,Cow,Horse,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm. Nucleus. Isoform LIMK2a is distributed in the cytoplasm and the nucleus and Cytoplasm. Nucleus. Isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus. |
| Tissue Specificity | Highest expression in the placenta; moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated synthesised phosphopeptide: human LIM Kinase 1 around the phosphorylation site of Thr505 |
| Antigen Species | Human |
| Gene Name | LIMK2 |
| Gene ID | |
| Protein Name | LIM domain kinase 2 |
| Uniprot ID | |
| Function | Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. |
| Molecular Weight | Theoretical: 70 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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