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PKCiota-IN-2

🥰Excellent
Catalog No. T9863Cas No. 2230055-52-2
Alias PKCiota-IN-49

PKCiota-IN-2 (PKCiota-IN-49) is a selective and potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively

PKCiota-IN-2

PKCiota-IN-2

🥰Excellent
Purity: 98.86%
Catalog No. T9863Alias PKCiota-IN-49Cas No. 2230055-52-2
PKCiota-IN-2 (PKCiota-IN-49) is a selective and potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$117In StockIn Stock
2 mg$175In StockIn Stock
5 mg$269In StockIn Stock
10 mg$395In StockIn Stock
25 mg$592In StockIn Stock
50 mg$834In StockIn Stock
100 mg$1,120In StockIn Stock
1 mL x 10 mM (in DMSO)$294In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98.86%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
PKCiota-IN-2 (PKCiota-IN-49) is a selective and potent PKCiota (PKC-ι) inhibitor with an IC50 of 2.8 nM. PKCiota-IN-2 also inhibits PKC-α and PKC-ε with IC50s of 71 nM and 350 nM, respectively
Targets&IC50
PKCα:71 nM, PKCε:350 nM, PKCι:2.8 nM
SynonymsPKCiota-IN-49
Chemical Properties
Molecular Weight395.46
FormulaC24H21N5O
Cas No.2230055-52-2
SmilesO(C)C1=C(C2=C3N(N=C2)C=CC(=C3)C4=C5C(=NC=C4)NC=C5)C=C6C(=C1)CCNC6
Relative Density.1.39 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (151.72 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5287 mL12.6435 mL25.2870 mL126.4350 mL
5 mM0.5057 mL2.5287 mL5.0574 mL25.2870 mL
10 mM0.2529 mL1.2644 mL2.5287 mL12.6435 mL
20 mM0.1264 mL0.6322 mL1.2644 mL6.3218 mL
50 mM0.0506 mL0.2529 mL0.5057 mL2.5287 mL
100 mM0.0253 mL0.1264 mL0.2529 mL1.2644 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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2 Enter the in vivo formulation:
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Keywords

PKC-ιPKCiota-IN-2
Related Tags: buy PKCiota-IN-2 | purchase PKCiota-IN-2 | PKCiota-IN-2 cost | order PKCiota-IN-2 | PKCiota-IN-2 chemical structure | PKCiota-IN-2 formula | PKCiota-IN-2 molecular weight
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