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PIK-294

Name: PIK-294
Brand: TargetMol
SKU: T2297
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2297Cas No. 900185-02-6

Alias PIK294

PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).

PIK-294

🥰Excellent

Purity: 99%

Catalog No. T2297Alias PIK294Cas No. 900185-02-6

PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$38	In Stock	In Stock
10 mg	$68	In Stock	In Stock
25 mg	$108	In Stock	In Stock
50 mg	$173	In Stock	In Stock
100 mg	$270	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$41	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99%

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COA

Product Introduction

Bioactivity

Description	PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).
Targets&IC50	p110β:490 nM, p110γ:160 nM, p110α:10 μM, p110δ:10 nM
In vivo	PIK-294 exhibits inhibitory effects on various PI3K isoforms, including p110β, p110δ, and p110γ; however, it demonstrates low selectivity towards p110α.
Synonyms	PIK294

Chemical Properties

Molecular Weight	489.53
Formula	C₂₈H₂₃N₇O₂
Cas No.	900185-02-6
Smiles	Cc1ccccc1-n1c(Cn2nc(-c3cccc(O)c3)c3c(N)ncnc23)nc2cccc(C)c2c1=O
Relative Density.	1.43 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 91 mg/mL (185.89 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.74 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0428 mL	10.2139 mL	20.4278 mL	102.1388 mL
5 mM	0.4086 mL	2.0428 mL	4.0856 mL	20.4278 mL
10 mM	0.2043 mL	1.0214 mL	2.0428 mL	10.2139 mL
20 mM	0.1021 mL	0.5107 mL	1.0214 mL	5.1069 mL
50 mM	0.0409 mL	0.2043 mL	0.4086 mL	2.0428 mL
100 mM	0.0204 mL	0.1021 mL	0.2043 mL	1.0214 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc