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SAR407899 hydrochloride

Name: SAR407899 hydrochloride
Brand: TargetMol
SKU: T23308
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23308Cas No. 923262-96-8

SAR407899 hydrochloride is a selective, potent, and ATP-competitive ROCK inhibitor with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.

SAR407899 hydrochloride

🥰Excellent

Purity: 99.15%

Catalog No. T23308Cas No. 923262-96-8

SAR407899 hydrochloride is a selective, potent, and ATP-competitive ROCK inhibitor with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.

Pack Size	Price	Availability
10 mg	$30	In Stock
25 mg	$54	In Stock
50 mg	$93	In Stock
100 mg	$148	In Stock
500 mg	$368	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.15%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	SAR407899 hydrochloride is a selective, potent, and ATP-competitive ROCK inhibitor with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.
Targets&IC50	ROCK1:276 nM (IC50), ROCK2:102 nM (IC50)

Chemical Properties

Molecular Weight	280.75
Formula	C₁₄H₁₇ClN₂O₂
Cas No.	923262-96-8
Smiles	Cl.O=c1[nH]ccc2cc(OC3CCNCC3)ccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (160.28 mM), Sonication is recommended.

H2O: 50 mg/mL (178.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.5619 mL	17.8094 mL	35.6189 mL	178.0944 mL
5 mM	0.7124 mL	3.5619 mL	7.1238 mL	35.6189 mL
10 mM	0.3562 mL	1.7809 mL	3.5619 mL	17.8094 mL
20 mM	0.1781 mL	0.8905 mL	1.7809 mL	8.9047 mL
50 mM	0.0712 mL	0.3562 mL	0.7124 mL	3.5619 mL
100 mM	0.0356 mL	0.1781 mL	0.3562 mL	1.7809 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc