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SAR407899 hydrochloride

Name: SAR407899 hydrochloride
Brand: TargetMol
SKU: T23308
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23308Cas No. 923262-96-8

SAR407899 hydrochloride is a selective, potent, and ATP-competitive ROCK inhibitor with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.

SAR407899 hydrochloride

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Purity: 99.15%

Catalog No. T23308Cas No. 923262-96-8

SAR407899 hydrochloride is a selective, potent, and ATP-competitive ROCK inhibitor with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$54	In Stock	In Stock
50 mg	$93	In Stock	In Stock
100 mg	$148	In Stock	In Stock
500 mg	$368	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.15%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

SAR407899 hydrochloride AI Summary

SAR407899 hydrochloride has demonstrated antiviral activity against SARS-CoV-2 by inhibiting the virus-induced cytotoxicity in both Caco-2 and VERO-6 cells. In high content imaging assays, SAR407899 hydrochloride showed an inhibition of 8.11% in the cytotoxicity of Caco-2 cells at a concentration of 10 µM after 48 hours of exposure. Additionally, the compound achieved an inhibition of 0.15% in VERO-6 cells under the same conditions. Furthermore, it exhibits inhibitory activity against the SARS-CoV-2 3CL-Pro protease, achieving an inhibition percentage of 18.98% at a concentration of 20 µM, as determined using a FRET response from a peptide substrate assay method. These findings suggest that SAR407899 hydrochloride has promising antiviral properties against SARS-CoV-2..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SAR407899 hydrochloride is a selective, potent, and ATP-competitive ROCK inhibitor with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.
Targets&IC50	ROCK1:276 nM (IC50), ROCK2:102 nM (IC50)

Chemical Properties

Molecular Weight	280.75
Formula	C₁₄H₁₇ClN₂O₂
Cas No.	923262-96-8
Smiles	Cl.O=c1[nH]ccc2cc(OC3CCNCC3)ccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (160.28 mM), Sonication is recommended.

H2O: 50 mg/mL (178.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.5619 mL	17.8094 mL	35.6189 mL	178.0944 mL
5 mM	0.7124 mL	3.5619 mL	7.1238 mL	35.6189 mL
10 mM	0.3562 mL	1.7809 mL	3.5619 mL	17.8094 mL
20 mM	0.1781 mL	0.8905 mL	1.7809 mL	8.9047 mL
50 mM	0.0712 mL	0.3562 mL	0.7124 mL	3.5619 mL
100 mM	0.0356 mL	0.1781 mL	0.3562 mL	1.7809 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc