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Anti-MUC1/CD227 Antibody (6D465)
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Catalog No. TMAB-09091
Anti-MUC1/CD227 Antibody (6D465) is a Rabbit antibody targeting MUC1/CD227. Anti-MUC1/CD227 Antibody (6D465) can be used in IHC-P,IF,IHC-Fr,WB.
Anti-MUC1/CD227 Antibody (6D465)
Anti-MUC1/CD227 Antibody (6D465)
😃Good
Catalog No. TMAB-09091
Anti-MUC1/CD227 Antibody (6D465) is a Rabbit antibody targeting MUC1/CD227. Anti-MUC1/CD227 Antibody (6D465) can be used in IHC-P,IF,IHC-Fr,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $151 | 7-10 days | 7-10 days | |
| 50 μL | $262 | 7-10 days | 7-10 days | |
| 100 μL | $471 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-MUC1/CD227 Antibody (6D465) is a Rabbit antibody targeting MUC1/CD227. Anti-MUC1/CD227 Antibody (6D465) can be used in IHC-P,IF,IHC-Fr,WB. |
| Ig Type | IgG |
| Clone | 6D465 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IHC-P: 1: 200-1000; IF: 1: 200-1000; IHC-Fr: 1: 200-1000; WB: 1: 500-2000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted; Cell membrane. Cytoplasm. Nucleus. On EGF and PDGFRB stimulation, transported to the nucleus through interaction with CTNNB1, a process which is stimulated by phosphorylation. On HRG stimulation, colocalizes with JUP/gamma-catenin at the nucleus and Apical cell membrane. Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. Located to microvilli and to the tips of long filopodial protusions. |
| Tissue Specificity | Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform 7 is expressed in tumor cells only. |
| Construction | Recombinant Antibody |
| Purification | Affinity Purification |
| Appearance | Liquid |
| Formulation | PBS with 100 μg/ml BSA, 0.15% ProClin300 and 50% glycerol. |
| Research Background | Mucins represent a family of glycoproteins characterized by repeat domains and dense O-glycosylation . MUC1 (or mucin 1) is aberrantly overexpressed in most human carcinomas. Increased expression of MUC1 in carcinomas reduces cell-cell and cell-ECM interactions. MUC1 is cleaved proteolytically, and the large ectodomain can remain associated with the small 25 kDa carboxy-terminal domain that contains a transmembrane segment and a 72-residue cytoplasmic tail. MUC1 interacts with ErbB family receptors and potentiates ERK1/2 activation. MUC1 also interacts with β-catenin, which is regulated by GSK-3β, PKCγ, and Src through phosphorylation at Ser44, Thr41, and Tyr46 of the MUC1 cytoplasmic tail. Overexpression of MUC1 potentiates transformation and attenuates stress-induced apoptosis through the Akt or p53 pathways |
| Immunogen | A synthesized peptide: Human MUC1 |
| Antigen Species | Human |
| Gene Name | MUC1 |
| Gene ID | |
| Protein Name | Mucin-1 |
| Uniprot ID | |
| Function | The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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