Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-length tau protein aggregates. Tau-aggregation and neuroinflammation-IN-1 has anti-inflammatory activity and reduces NO release.Tau-aggregation and neuroinflammation-IN-1 has low cytotoxicity against LSP-stimulated BV2 cells.Tau-aggregation and neuroinflammation-IN-1 reverses okadaic acid-induced memory impairment in rats.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 122.00 | |
50 mg | In stock | $ 197.00 | |
100 mg | In stock | $ 293.00 |
Description | Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-length tau protein aggregates. Tau-aggregation and neuroinflammation-IN-1 has anti-inflammatory activity and reduces NO release.Tau-aggregation and neuroinflammation-IN-1 has low cytotoxicity against LSP-stimulated BV2 cells.Tau-aggregation and neuroinflammation-IN-1 reverses okadaic acid-induced memory impairment in rats. |
In vitro |
Tau-aggregation and neuroinflammation-IN-1 (compound 30) (0-40 μM) reduces the survival of SH-SY5Y cells at 30 μM. It does not show significant hepatotoxicity at high concentrations in LO2 cells, nor does it have any effect on the viability of BV2 cells at 20 μM.[1] Tau-aggregation and neuroinflammation-IN-1 (2.5, 5, and 10 μM; 24 h) maintain the anti-inflammatory effect of sodium usage and reduce the NO release rate by 41% at 10 μM in LPS-stimulated BV2 cells.[1] |
In vivo | Tau-aggregation and neuroinflammation-IN-1 (5 and 10 mg/kg; I.P.; for 7 days, and after OA-injection continued IP for 7 days; Male SD rats) leads to a substantial improvement of the conventional reference spatial memory and cognitive abilities of OA-induced rats.[1] |
Molecular Weight | 460.44 |
Formula | C25H20N2O7 |
CAS No. | 2175953-98-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40.04 mg/mL (100 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Tau-aggregation and neuroinflammation-IN-1 2175953-98-5 Cytoskeletal Signaling Immunology/Inflammation NO Synthase Microtubule Associated inhibitor inhibit