Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MKA031 (compound 6y) is a non-competitive inhibitor of macrophage migration inhibitory factor (MIF), exhibiting an IC50 of 1.7 μM. It disrupts the MIF-aryl hydrocarbon receptor interacting protein (AIF) interaction, impedes MIF nuclear translocation, and mitigates N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced cell death. MKA031 is applicable in research on chronic hepatitis C virus infection [1].
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Description | MKA031 (compound 6y) is a non-competitive inhibitor of macrophage migration inhibitory factor (MIF), exhibiting an IC50 of 1.7 μM. It disrupts the MIF-aryl hydrocarbon receptor interacting protein (AIF) interaction, impedes MIF nuclear translocation, and mitigates N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced cell death. MKA031 is applicable in research on chronic hepatitis C virus infection [1]. |
In vitro | MKA031 (compound 6y) at a volume of 1-100 μl for 3 hours inhibits cell death induced by MNNG [1]. At a concentration of 100 μl for the same duration, it protects genomic DNA by preventing the recruitment of MIF to AIF [1]. |
Molecular Weight | 403.46 |
Formula | C21H17N5O2S |
CAS No. | 2951012-00-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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MKA031 2951012-00-1 inhibitor inhibit