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Anti-ZEB1 Antibody (5M128)
😃Good
Catalog No. TMAB-14284
Anti-ZEB1 Antibody (5M128) is a Mouse antibody targeting ZEB1. Anti-ZEB1 Antibody (5M128) can be used in WB,FCM.
Anti-ZEB1 Antibody (5M128)
Anti-ZEB1 Antibody (5M128)
😃Good
Catalog No. TMAB-14284
Anti-ZEB1 Antibody (5M128) is a Mouse antibody targeting ZEB1. Anti-ZEB1 Antibody (5M128) can be used in WB,FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-ZEB1 Antibody (5M128) is a Mouse antibody targeting ZEB1. Anti-ZEB1 Antibody (5M128) can be used in WB,FCM. |
| Ig Type | IgG1, k |
| Clone | 5M128 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1:500-2000; FCM: 1:10-50 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Subcellular Localization | Nucleus. |
| Tissue Specificity | Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Protein G purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010] |
| Immunogen | KLH conjugated synthetic peptide: human ZEB1 |
| Antigen Species | Human |
| Gene Name | ZEB1 |
| Gene ID | |
| Protein Name | Zinc finger E-box-binding homeobox 1 |
| Uniprot ID | |
| Function | Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. |
| Molecular Weight | Theoretical: 124 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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