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TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

Complement C5-IN-1

🥰Excellent
Catalog No. T10863Cas No. 2365402-67-9

Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).

Complement C5-IN-1

Complement C5-IN-1

🥰Excellent
Purity: 98.27%
Catalog No. T10863Cas No. 2365402-67-9
Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).
Pack SizePriceAvailabilityQuantity
1 mg$93In Stock
5 mg$191In Stock
10 mg$277In Stock
25 mg$428In Stock
50 mg$569In Stock
100 mg$773In Stock
200 mg$987In Stock
1 mL x 10 mM (in DMSO)$211In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:98.27%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Complement C5-IN-1 is a small-molecule inhibitor of complement component 5 protein (C5).
In vitro
Complement C5-IN-1 (Compound 7) interacts with C5 to prevent its cleavage by the C5 convertase and blocks zymosan-induced the membrane-attack complex (MAC) deposition in 50% human whole blood (IC50: 0.77 µM)[1].
Chemical Properties
Molecular Weight444.52
FormulaC24H32N2O6
Cas No.2365402-67-9
SmilesCOc1ccccc1[C@H](C)NC(=O)Nc1cc(OCCCC(C)C)c(OC)cc1C(O)=O
Relative Density.1.179 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 90 mg/mL (202.47 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.42 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2496 mL11.2481 mL22.4962 mL112.4809 mL
5 mM0.4499 mL2.2496 mL4.4992 mL22.4962 mL
10 mM0.2250 mL1.1248 mL2.2496 mL11.2481 mL
20 mM0.1125 mL0.5624 mL1.1248 mL5.6240 mL
50 mM0.0450 mL0.2250 mL0.4499 mL2.2496 mL
100 mM0.0225 mL0.1125 mL0.2250 mL1.1248 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ComplementSystemComplement SystemComplement C5-IN-1Complement C-5-IN-1Complement C5IN1Complement C5 IN 1Complement C5
Related Tags: buy Complement C5-IN-1 | purchase Complement C5-IN-1 | Complement C5-IN-1 cost | order Complement C5-IN-1 | Complement C5-IN-1 chemical structure | Complement C5-IN-1 in vitro | Complement C5-IN-1 formula | Complement C5-IN-1 molecular weight
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