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AZ044

Name: AZ044
Brand: TargetMol
SKU: T26698
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26698Cas No. 1800017-49-5

AZ044 is a potent, selective inhibitor of type III phosphatidylinositol-4-kinase alpha-subtype (PI4KIIIalpha).

AZ044

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Purity: 99.5%

Catalog No. T26698Cas No. 1800017-49-5

AZ044 is a potent, selective inhibitor of type III phosphatidylinositol-4-kinase alpha-subtype (PI4KIIIalpha).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$52	In Stock	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$455	In Stock	In Stock
50 mg	$787	In Stock	In Stock
100 mg	$1,280	In Stock	In Stock
200 mg	$1,730	-	In Stock
1 mL x 10 mM (in DMSO)	$135	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.5%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

AZ044 AI Summary

AZ044 demonstrates potent bioactivity as an inhibitor of various kinases and phosphatidylinositol enzymes. It exhibits high potency in inhibiting PI4K3alpha with an IC50 of 1.0 nM and moderate inhibition of PI4K3beta with an IC50 of 251.19 nM. Additionally, it shows activity against PI3Kgamma with an IC50 of 10000.0 nM and PI4K3alpha in mouse NIH3T3 cells with an IC50 of 316.23 nM. However, it has significantly lower activity against PI3Kalpha (IC50 of 100000.0 nM), PI3Kbeta (IC50 > 199526.23 nM), and PI3Kdelta (IC50 > 79432.82 nM)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	AZ044 is a potent, selective inhibitor of type III phosphatidylinositol-4-kinase alpha-subtype (PI4KIIIalpha).
Targets&IC50	PI3Kγ:5.0 (pIC50), PI4KIIIα:9.0 (pIC50), PI3Kα:4.0 (pIC50), PI4KIIIβ:6.6 (pIC50), PI3Kβ:<3.7 (pIC50), PI3Kδ:<4.1 (pIC50)

Chemical Properties

Molecular Weight	437.55
Formula	C₂₄H₂₇N₃O₃S
Cas No.	1800017-49-5
Smiles	N(C[C@@H]1CC[C@@H](C(O)=O)CC1)C=2SC=3C(N2)=CC=C(C3)C4=CC(=O)N(CC5CC5)C=C4
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 22.5 mg/mL (51.42 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2855 mL	11.4273 mL	22.8545 mL	114.2727 mL
5 mM	0.4571 mL	2.2855 mL	4.5709 mL	22.8545 mL
10 mM	0.2285 mL	1.1427 mL	2.2855 mL	11.4273 mL
20 mM	0.1143 mL	0.5714 mL	1.1427 mL	5.7136 mL
50 mM	0.0457 mL	0.2285 mL	0.4571 mL	2.2855 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc