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UNC926 hydrochloride

Name: UNC926 hydrochloride
Brand: TargetMol
SKU: T9221
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9221Cas No. 1782573-49-2

UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.

UNC926 hydrochloride

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Purity: 99.93%

Catalog No. T9221Cas No. 1782573-49-2

UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$80	-	In Stock
5 mg	$181	-	In Stock
10 mg	$272	-	In Stock
25 mg	$448	-	In Stock
50 mg	$630	-	In Stock
100 mg	$852	-	In Stock
200 mg	$1,130	-	In Stock
1 mL x 10 mM (in DMSO)	$187	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.93%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	UNC926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor.
Targets&IC50	L3MBTL1:3.9 μM, L3MBTL4:15.6 μM, L3MBTL3:3.2 μM
In vitro	UNC926 demonstrates a low micromolar affinity toward L3MBTL3, exhibiting an IC50 of 3.2 μM, and shows diminished affinity for other MBT domains without binding to CBX7. In a concentration-dependent manner ranging from 1-25 μM, UNC926 effectively inhibits the interaction between the 3xMBT domain and H4K20me1 and impedes the association of L3MBTL1's 3xMBT with specific histone peptides. However, it does not disrupt the binding of 53BP1 to H4K20me1, indicating that UNC926 specifically targets L3MBTL1 rather than 53BP1.

Chemical Properties

Molecular Weight	373.72
Formula	C₁₆H₂₂BrClN₂O
Cas No.	1782573-49-2
Smiles	O=C(C1=CC=CC(Br)=C1)N2CCC(N3CCCC3)CC2.[H]Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (401.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6758 mL	13.3790 mL	26.7580 mL	133.7900 mL
5 mM	0.5352 mL	2.6758 mL	5.3516 mL	26.7580 mL
10 mM	0.2676 mL	1.3379 mL	2.6758 mL	13.3790 mL
20 mM	0.1338 mL	0.6690 mL	1.3379 mL	6.6895 mL
50 mM	0.0535 mL	0.2676 mL	0.5352 mL	2.6758 mL
100 mM	0.0268 mL	0.1338 mL	0.2676 mL	1.3379 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc