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Anti-TIM-3/KIM-3/HAVCR2 Antibody (5P71)
🥰Excellent
Catalog No. TMAY-03558
Anti-TIM-3/KIM-3/HAVCR2 Antibody (5P71) is a Rabbit antibody targeting TIM-3/KIM-3/HAVCR2. Anti-TIM-3/KIM-3/HAVCR2 Antibody (5P71) can be used in ELISA.
Anti-TIM-3/KIM-3/HAVCR2 Antibody (5P71)
Anti-TIM-3/KIM-3/HAVCR2 Antibody (5P71)
🥰Excellent
Catalog No. TMAY-03558
Anti-TIM-3/KIM-3/HAVCR2 Antibody (5P71) is a Rabbit antibody targeting TIM-3/KIM-3/HAVCR2. Anti-TIM-3/KIM-3/HAVCR2 Antibody (5P71) can be used in ELISA.
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Chemical Properties
| Description | Anti-TIM-3/KIM-3/HAVCR2 Antibody (5P71) is a Rabbit antibody targeting TIM-3/KIM-3/HAVCR2. Anti-TIM-3/KIM-3/HAVCR2 Antibody (5P71) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5P71 |
| Reactivity | Mouse |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse TIM-3 (rM TIM-3; TMPY-03424; AAL65156.1; Met1-Arg191). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Hepatitis A virus cellular receptor 2 (HAVCR2), formerly known as T cell immunoglobulin and mucin domain-3 (TIM-3), is a transmembrane glycoprotein expressed on the surface of terminally differentiated Th1 cells but not on Th2 cells. It was the first surface molecule that specifically identifies Th1 cells in both the mouse and human. Recently, the identification of Galectin-9 as a ligand for TIM-3 has established the TIM-3-Galectin-9 pathway as an important regulator of Th1 immunity and tolerance induction. Engagement of Tim-3 by its ligand galectin-9 negatively regulates IFN-gamma secretion and influences the ability to induce T cell tolerance in both mice and man. It suggests a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis. Recent work has explored the role of TIM-3 in systemic lupus erythematosus (SLE), and their results indicate that TIM-3 may represent a novel target for the treatment of SLE. Numerous studies have demonstrated that Tim-3 influences autoimmune diseases, including diabetes and multiple sclerosis, and its role in other inflammatory diseases including allergies and cancer is beginning to become clear. In the tumor rejection model, the soluble form of Tim-3 (sTim-3) significantly impaired T cell antitumor immunity, evidenced by decreased antitumor CTL activity and reduced amount of tumor-infiltrating lymphocytes in the tumor. sTim-3 as an immunoregulatory molecule that may be involved in the negative regulation of T cell-mediated immune response.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse TIM-3 Protein (TMPY-03424) |
| Antigen Species | Mouse |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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