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SEP-363856 hydrochloride

Name: SEP-363856 hydrochloride
Brand: TargetMol
SKU: T12899L
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12899LCas No. 1310422-41-3

Alias SEP-856 hydrochloride

SEP-363856 hydrochloride (SEP-856 hydrochloride) is an orally active, CNS-active psychotropic agent with a unique non-D2/5-HT2A mechanism of action, demonstrating antipsychotic-like effects and potential for schizophrenia treatment.

SEP-363856 hydrochloride

🥰Excellent

Purity: 99.99%

Catalog No. T12899LAlias SEP-856 hydrochlorideCas No. 1310422-41-3

Pack Size	Price	Availability
1 mg	$64	In Stock
2 mg	$93	In Stock
5 mg	$156	In Stock
10 mg	$255	In Stock
25 mg	$448	In Stock
50 mg	$662	In Stock
100 mg	$987	In Stock
500 mg	$1,980	In Stock
1 mL x 10 mM (in DMSO)	$172	In Stock

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Purity:99.99%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	SEP-363856 hydrochloride (SEP-856 hydrochloride) is an orally active, CNS-active psychotropic agent with a unique non-D2/5-HT2A mechanism of action, demonstrating antipsychotic-like effects and potential for schizophrenia treatment.
Targets&IC50	5-HT2C receptor:30 μM （EC50）, TAAR1:0.140 μM （EC50）, 5-HT7 receptor:6.7 μM （EC50）, 5-HT1B receptor:15.6 μM （EC50）, 5-HT2A receptor:10 μM （EC50）, 5-HT1D receptor:0.262 μM （EC50）, 5-HT1A receptor:2.3 μM （EC50）
In vitro	SEP-856 (10μM) specifically inhibits α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C and 5-HT7> 50% receptor.
In vivo	SEP-856 (0.3, 1, and 10 mg/kg, i.p.) is CNS active and exhibits a behavioral signature similar to known antipsychotic drugs. PCP-induced hyperactivity is significantly reduced by SEP-856 (0.3, 1, and 10 mg/kg, orally once). Oral SEP-856 administration (1, 3, and 10 mg/kg) produces a dose-dependent decrease in REM sleep, increase in latency to REM sleep, and increase in cumulative wake (W) time.
Synonyms	SEP-856 hydrochloride

Chemical Properties

Molecular Weight	219.73
Formula	C₉H₁₄ClNOS
Cas No.	1310422-41-3
Smiles	Cl.CNC[C@@H]1OCCc2ccsc12
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (250.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5510 mL	22.7552 mL	45.5104 mL	227.5520 mL
5 mM	0.9102 mL	4.5510 mL	9.1021 mL	45.5104 mL
10 mM	0.4551 mL	2.2755 mL	4.5510 mL	22.7552 mL
20 mM	0.2276 mL	1.1378 mL	2.2755 mL	11.3776 mL
50 mM	0.0910 mL	0.4551 mL	0.9102 mL	4.5510 mL
100 mM	0.0455 mL	0.2276 mL	0.4551 mL	2.2755 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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