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SEP-363856 hydrochloride

Name: SEP-363856 hydrochloride
Brand: TargetMol
SKU: T12899L
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12899LCas No. 1310422-41-3

Alias SEP-856 hydrochloride

SEP-363856 hydrochloride (SEP-856 hydrochloride) is an orally active, CNS-active psychotropic agent with a unique non-D2/5-HT2A mechanism of action, demonstrating antipsychotic-like effects and potential for schizophrenia treatment.

SEP-363856 hydrochloride

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Purity: 99.99%

Catalog No. T12899LAlias SEP-856 hydrochlorideCas No. 1310422-41-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
2 mg	$93	In Stock	In Stock
5 mg	$156	In Stock	In Stock
10 mg	$255	In Stock	In Stock
25 mg	$448	In Stock	In Stock
50 mg	$662	In Stock	In Stock
100 mg	$987	In Stock	In Stock
500 mg	$1,980	-	In Stock
1 mL x 10 mM (in DMSO)	$172	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.99%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	SEP-363856 hydrochloride (SEP-856 hydrochloride) is an orally active, CNS-active psychotropic agent with a unique non-D2/5-HT2A mechanism of action, demonstrating antipsychotic-like effects and potential for schizophrenia treatment.
Targets&IC50	5-HT2C receptor:30 μM （EC50）, 5-HT1D receptor:0.262 μM （EC50）, 5-HT1B receptor:15.6 μM （EC50）, 5-HT7 receptor:6.7 μM （EC50）, 5-HT1A receptor:2.3 μM （EC50）, TAAR1:0.140 μM （EC50）, 5-HT2A receptor:10 μM （EC50）
In vitro	SEP-856 (10μM) specifically inhibits α2A, α2B, D2, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C and 5-HT7> 50% receptor.
In vivo	SEP-856 (0.3, 1, and 10 mg/kg, i.p.) is CNS active and exhibits a behavioral signature similar to known antipsychotic drugs. PCP-induced hyperactivity is significantly reduced by SEP-856 (0.3, 1, and 10 mg/kg, orally once). Oral SEP-856 administration (1, 3, and 10 mg/kg) produces a dose-dependent decrease in REM sleep, increase in latency to REM sleep, and increase in cumulative wake (W) time.
Synonyms	SEP-856 hydrochloride

Chemical Properties

Molecular Weight	219.73
Formula	C₉H₁₄ClNOS
Cas No.	1310422-41-3
Smiles	Cl.CNC[C@@H]1OCCc2ccsc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (250.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (22.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5510 mL	22.7552 mL	45.5104 mL	227.5520 mL
5 mM	0.9102 mL	4.5510 mL	9.1021 mL	45.5104 mL
10 mM	0.4551 mL	2.2755 mL	4.5510 mL	22.7552 mL
20 mM	0.2276 mL	1.1378 mL	2.2755 mL	11.3776 mL
50 mM	0.0910 mL	0.4551 mL	0.9102 mL	4.5510 mL
100 mM	0.0455 mL	0.2276 mL	0.4551 mL	2.2755 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc