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LP 12 hydrochloride

Name: LP 12 hydrochloride
Brand: TargetMol
SKU: T37073
Rating: 4.5 (1 reviews)

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Catalog No. T37073Cas No. 1185136-22-4

LP 12 hydrochloride is a selective 5-HT7 receptor agonist (Ki=0.13 nM). LP 12 hydrochloride is selective for 5-HT7 over D2, 5-HT1A, and 5-HT2A receptors (Ki values of 224 nM, 60.9 nM, and >1000 nM, respectively).

LP 12 hydrochloride

😃Good

Catalog No. T37073Cas No. 1185136-22-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$1,520	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	LP 12 hydrochloride is a selective 5-HT7 receptor agonist (Ki=0.13 nM). LP 12 hydrochloride is selective for 5-HT7 over D2, 5-HT1A, and 5-HT2A receptors (Ki values of 224 nM, 60.9 nM, and >1000 nM, respectively).
Targets&IC50	5-HT7 receptor:0.13 nM (IC50), 5-HT2A receptor:1464 nM (IC50), 5-HT1A receptor:60.9 nM (IC50)

Chemical Properties

Molecular Weight	518.14
Formula	C₃₂H₄₀ClN₃O
Cas No.	1185136-22-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: > 10 mM, Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9300 mL	9.6499 mL	19.2998 mL	96.4990 mL
5 mM	0.3860 mL	1.9300 mL	3.8600 mL	19.2998 mL
10 mM	0.1930 mL	0.9650 mL	1.9300 mL	9.6499 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc