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Tyrosine kinase inhibitor

Name: Tyrosine kinase inhibitor
Brand: TargetMol
SKU: T17184
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T17184Cas No. 1021950-26-4

Tyrosine kinase inhibitor is a tyrosine kinase inhibitor used in combination with fragmenting aromatic nitrogen compounds as antiproliferative agents.

Tyrosine kinase inhibitor

🥰Excellent

Catalog No. T17184Cas No. 1021950-26-4

Tyrosine kinase inhibitor is a tyrosine kinase inhibitor used in combination with fragmenting aromatic nitrogen compounds as antiproliferative agents.

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Product Introduction

Bioactivity

Description

Tyrosine kinase inhibitor is a tyrosine kinase inhibitor used in combination with fragmenting aromatic nitrogen compounds as antiproliferative agents.

In vitro

Tyrosine kinases play crucial roles in diverse biological processes such as growth, differentiation, metabolism, and apoptosis in response to stimuli. Recent findings highlight their involvement in cancer pathophysiology. Although normally regulated, tyrosine kinases may gain transforming functions through mutation(s), overexpression, or autocrine/paracrine stimulation, causing malignancy. Selective tyrosine kinase inhibitors can block constitutive oncogenic activation in cancer cells, offering a promising approach for innovative genome-based therapeutics.

Chemical Properties

Molecular Weight	586.61
Formula	C₃₁H₃₁FN₆O₅
Cas No.	1021950-26-4
Smiles	Fc1ccc(NC(=O)C2(CC2)C(=O)Nc2ccc(Oc3ccnc4[nH]c(cc34)C(=O)NCCN3CCOCC3)cc2)cc1
Relative Density.	1.428 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (76.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (3.41 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7047 mL	8.5236 mL	17.0471 mL	85.2355 mL
5 mM	0.3409 mL	1.7047 mL	3.4094 mL	17.0471 mL
10 mM	0.1705 mL	0.8524 mL	1.7047 mL	8.5236 mL
20 mM	0.0852 mL	0.4262 mL	0.8524 mL	4.2618 mL
50 mM	0.0341 mL	0.1705 mL	0.3409 mL	1.7047 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc