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Tyrosine kinase inhibitor

Name: Tyrosine kinase inhibitor
Brand: TargetMol
SKU: T17184
Rating: 4.5 (1 reviews)

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Catalog No. T17184Cas No. 1021950-26-4

Tyrosine kinase inhibitor is a tyrosine kinase inhibitor used in combination with fragmenting aromatic nitrogen compounds as antiproliferative agents.

Tyrosine kinase inhibitor

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Catalog No. T17184Cas No. 1021950-26-4

Tyrosine kinase inhibitor is a tyrosine kinase inhibitor used in combination with fragmenting aromatic nitrogen compounds as antiproliferative agents.

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Product Introduction

Bioactivity

Description

Tyrosine kinase inhibitor is a tyrosine kinase inhibitor used in combination with fragmenting aromatic nitrogen compounds as antiproliferative agents.

In vitro

Tyrosine kinases play crucial roles in diverse biological processes such as growth, differentiation, metabolism, and apoptosis in response to stimuli. Recent findings highlight their involvement in cancer pathophysiology. Although normally regulated, tyrosine kinases may gain transforming functions through mutation(s), overexpression, or autocrine/paracrine stimulation, causing malignancy. Selective tyrosine kinase inhibitors can block constitutive oncogenic activation in cancer cells, offering a promising approach for innovative genome-based therapeutics.

Chemical Properties

Molecular Weight	586.61
Formula	C₃₁H₃₁FN₆O₅
Cas No.	1021950-26-4
Smiles	Fc1ccc(NC(=O)C2(CC2)C(=O)Nc2ccc(Oc3ccnc4[nH]c(cc34)C(=O)NCCN3CCOCC3)cc2)cc1
Relative Density.	1.428 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (76.71 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (3.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7047 mL	8.5236 mL	17.0471 mL	85.2355 mL
5 mM	0.3409 mL	1.7047 mL	3.4094 mL	17.0471 mL
10 mM	0.1705 mL	0.8524 mL	1.7047 mL	8.5236 mL
20 mM	0.0852 mL	0.4262 mL	0.8524 mL	4.2618 mL
50 mM	0.0341 mL	0.1705 mL	0.3409 mL	1.7047 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc