Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 128.00 | |
50 mg | In stock | $ 213.00 | |
100 mg | In stock | $ 318.00 |
Description | PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development. |
Targets&IC50 | PARP1:302 μM |
In vitro | PARP-1-IN-4 exhibits inhibitory activity against PARP-1, with an IC50 value of 302 μM[1]. It demonstrates cytotoxicity against A549 cells at concentrations of 0.1, 1, and 10 μM for 24h and 48h[1]. Treatment with PARP-1-IN-4 at 1 μM for 24h significantly increases the expression levels of caspase-3 and caspase-9 proteins[1]. |
Molecular Weight | 424.28 |
Formula | C22H15Cl2N3O2 |
CAS No. | 684234-56-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (11.78 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PARP-1-IN-4 684234-56-8 Chromatin/Epigenetic DNA Damage/DNA Repair Others PARP inhibitor inhibit