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Biotin-PEG12-NHS ester

Name: Biotin-PEG12-NHS ester
Brand: TargetMol
SKU: T17561
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17561Cas No. 1934296-88-4

Biotin-PEG12-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs.

Biotin-PEG12-NHS ester

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Purity: 98.00%

Catalog No. T17561Cas No. 1934296-88-4

Biotin-PEG12-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$58	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$145	In Stock	In Stock
100 mg	$215	-	In Stock
200 mg	$318	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$67	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.00%

Appearance:Viscous

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Biotin-PEG12-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs.
In vitro	PROTACs consist of two ligands connected by a linker: one targets an E3 ubiquitin ligase, and the other binds to the target protein, utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Chemical Properties

Molecular Weight	941.09
Formula	C₄₁H₇₂N₄O₁₈S
Cas No.	1934296-88-4
Smiles	C(CCCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O)=O)[C@H]2[C@@]3([C@](CS2)(NC(=O)N3)[H])[H]
Relative Density.	1.26 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (265.65 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0626 mL	5.3130 mL	10.6260 mL	53.1299 mL
5 mM	0.2125 mL	1.0626 mL	2.1252 mL	10.6260 mL
10 mM	0.1063 mL	0.5313 mL	1.0626 mL	5.3130 mL
20 mM	0.0531 mL	0.2656 mL	0.5313 mL	2.6565 mL
50 mM	0.0213 mL	0.1063 mL	0.2125 mL	1.0626 mL
100 mM	0.0106 mL	0.0531 mL	0.1063 mL	0.5313 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc