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Deglycobleomycin

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Catalog No. T210875Cas No. 78314-57-5

Deglycobleomycin is an RNA cleaving agent that targets r(CUG) repeat sequences. By binding with small molecules that recognize r(CUG)exp, Deglycobleomycin can selectively cleave r(CUG)exp. Its efficiency in cleaving DNA is considerably lower than that of Bleomycin A5(Pingyangmycin), but it exhibits enhanced selectivity for r(CUG)exp. Deglycobleomycin is useful for research on diseases associated with r(CUG) repeat expansions, such as myotonic dystrophy type 1, and the development of drugs aimed at precise targeting and cleavage of pathogenic RNA.

Deglycobleomycin

Deglycobleomycin

😃Good
Catalog No. T210875Cas No. 78314-57-5
Deglycobleomycin is an RNA cleaving agent that targets r(CUG) repeat sequences. By binding with small molecules that recognize r(CUG)exp, Deglycobleomycin can selectively cleave r(CUG)exp. Its efficiency in cleaving DNA is considerably lower than that of Bleomycin A5(Pingyangmycin), but it exhibits enhanced selectivity for r(CUG)exp. Deglycobleomycin is useful for research on diseases associated with r(CUG) repeat expansions, such as myotonic dystrophy type 1, and the development of drugs aimed at precise targeting and cleavage of pathogenic RNA.
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Product Introduction

Bioactivity
Description
Deglycobleomycin is an RNA cleaving agent that targets r(CUG) repeat sequences. By binding with small molecules that recognize r(CUG)exp, Deglycobleomycin can selectively cleave r(CUG)exp. Its efficiency in cleaving DNA is considerably lower than that of Bleomycin A5(Pingyangmycin), but it exhibits enhanced selectivity for r(CUG)exp. Deglycobleomycin is useful for research on diseases associated with r(CUG) repeat expansions, such as myotonic dystrophy type 1, and the development of drugs aimed at precise targeting and cleavage of pathogenic RNA.
Chemical Properties
Molecular Weight1058.20
FormulaC42H63N19O10S2
Cas No.78314-57-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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