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Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA

Name: Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA
Brand: TargetMol
SKU: TP3334
Rating: 4.5 (1 reviews)

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Catalog No. TP3334

Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA), is a neuropeptide from the calcitonin family composed of 37 amino acids and functions via (CRLR).

Calcitonin Gene Related Peptide (CGRP) (83-119), rat TFA

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Catalog No. TP3334

Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA), is a neuropeptide from the calcitonin family composed of 37 amino acids and functions via (CRLR).

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA), is a neuropeptide from the calcitonin family composed of 37 amino acids and functions via (CRLR).
In vitro	Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA), is part of the calcitonin family of neuropeptides, which includes adrenomedullin, amylin, calcitonin, intermedin, and calcitonin receptor-stimulating peptide. It has two isoforms, αCGRP and βCGRP, and interacts with the calcitonin receptor-like receptor (CRLR). CGRP is significant in migraine pathophysiology and is linked to the activation of the trigeminovascular system. It potentially acts postjunctionally in areas involved in primary headaches.
In vivo	Calcitonin Gene Related Peptide (CGRP) (83-119), rat (TFA), is highly effective at causing oedema in rat orofacial tissue. When administered at a concentration of 100 μL (8-33 pM), CGRP produces a rapidly onset (5-15 min) and prolonged (6 h), dose-dependent swelling in the rat cheek. Additionally, it induces a less pronounced oedematogenic response in the rat hind paw, which can be inhibited by a CGRP antagonist. Furthermore, CGRP (16 pM) enhances the oedema caused by the simultaneous injection of substance P (3.7 nM).

Chemical Properties

Formula	C₁₆₂H₂₆₂N₅₀O₅₂S₂.C₂HF₃O₂
Sequence	Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge: Cys2-Cys7)(TFA salt)
Sequence Short	SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF (Disulfide bridge: Cys2-Cys7)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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