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Fosphenytoin
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Catalog No. T61354Cas No. 93390-81-9
Fosphenytoin is a phosphate prodrug that can be used as an alternative to intravenous phenytoin for the acute intervention of seizures.Fosphenytoin is hydrolyzed to anticonvulsant phenytoin when administered parenterally.Fosphenytoin can be used in a variety of delivery modes such as intravenous and intraperitoneal.Fosphenytoin can be used in a variety of delivery modes such as intravenous and intraperitoneal.
Fosphenytoin
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Purity: 98.51%
Catalog No. T61354Cas No. 93390-81-9
Fosphenytoin is a phosphate prodrug that can be used as an alternative to intravenous phenytoin for the acute intervention of seizures.Fosphenytoin is hydrolyzed to anticonvulsant phenytoin when administered parenterally.Fosphenytoin can be used in a variety of delivery modes such as intravenous and intraperitoneal.Fosphenytoin can be used in a variety of delivery modes such as intravenous and intraperitoneal.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $39 | In Stock | In Stock | |
| 10 mg | $55 | In Stock | In Stock | |
| 25 mg | $82 | In Stock | In Stock | |
| 50 mg | $97 | In Stock | In Stock | |
| 100 mg | $155 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:98.51%
Appearance:Solid
Color:White
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Product Introduction
Fosphenytoin AI Summary
Fosphenytoin exhibits a range of bioactivities impacting liver function and enzymatic processes, notably including increases in alkaline phosphatase, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), lactate dehydrogenase (LDH), and gamma-glutamyl transferase (GGT). It has a moderate risk of drug-induced liver injury with a Hepatic Side Effect (HepSE) score of 1.0 specifically for liver function tests abnormal, though it shows no adverse effects (HepSE score of 0.0) for conditions like bilirubinemia, cholecystitis, and cirrhosis among others. The compound also demonstrates potential antiviral activity, having been tested in PubChem BioAssays for Ebola virus entry inhibition, showing variable AC50 values in different test channels. Additionally, Fosphenytoin was assessed for its action against SARS-CoV-2 (USA-WA1/2020 strain) with a hit score of -0.01075. It inhibits human HDAC6 enzymatic activity with a considerable inhibitory effect of 37.12% using a commercial peptide substrate, although this inhibition falls significantly to 0.73% with a custom peptide substrate. Furthermore, the severity class index for drug-induced liver injury associated with this compound is 8.0..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Fosphenytoin is a phosphate prodrug that can be used as an alternative to intravenous phenytoin for the acute intervention of seizures.Fosphenytoin is hydrolyzed to anticonvulsant phenytoin when administered parenterally.Fosphenytoin can be used in a variety of delivery modes such as intravenous and intraperitoneal.Fosphenytoin can be used in a variety of delivery modes such as intravenous and intraperitoneal. |
| Molecular Weight | 362.27 |
| Formula | C16H15N2O6P |
| Cas No. | 93390-81-9 |
| Smiles | O=C1C(NC(=O)N1COP(=O)(O)O)(C2=CC=CC=C2)C3=CC=CC=C3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 125 mg/mL (345.05 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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