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Anti-inflammatory agent 91
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Catalog No. T89600
Anti-inflammatory agent 91 (Compound 4o) is a chemical compound known for its efficacy in reducing inflammatory cytokines by inhibiting the STAT3 and NF-κB signaling pathways. It is utilized in research to study its potential in ameliorating skin inflammation associated with psoriasis.
Anti-inflammatory agent 91
Anti-inflammatory agent 91
😃Good
Catalog No. T89600
Anti-inflammatory agent 91 (Compound 4o) is a chemical compound known for its efficacy in reducing inflammatory cytokines by inhibiting the STAT3 and NF-κB signaling pathways. It is utilized in research to study its potential in ameliorating skin inflammation associated with psoriasis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Anti-inflammatory agent 91 (Compound 4o) is a chemical compound known for its efficacy in reducing inflammatory cytokines by inhibiting the STAT3 and NF-κB signaling pathways. It is utilized in research to study its potential in ameliorating skin inflammation associated with psoriasis. |
| In vitro | Compound 4o (Anti-inflammatory agent 91) at concentrations of 10-80 μM for 24 hours does not significantly affect the viability of HaCaT cells. However, when used at 10-40 μM for 2 hours, it significantly reduces the levels of NO (IC 50 = 19.5 μM), TNF-α, and IL-6 in RAW264.7 cells, as well as IL-17A in HaCaT cells, when induced by LPS (1 μg/mL; 24 h). This demonstrates its anti-inflammatory activity in these cell lines. |
| In vivo | The anti-inflammatory agent 91 (Compound 4o) (25-100 mg/kg;) enhances psoriasis conditions in mice induced by imiquimod by inhibiting inflammatory cytokines. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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