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Naloxegol oxalate

Name: Naloxegol oxalate
Brand: TargetMol
SKU: T3355
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3355Cas No. 1354744-91-4

Alias NKTR-118 oxalate, NKTR118 oxalate, AZ-13337019 oxalate, AZ 13337019 oxalate

Naloxegol oxalate (NKTR-118) is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation.

Naloxegol oxalate

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Purity: 99.67%

Catalog No. T3355Alias NKTR-118 oxalate, NKTR118 oxalate, AZ-13337019 oxalate, AZ 13337019 oxalateCas No. 1354744-91-4

Naloxegol oxalate (NKTR-118) is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	In Stock	In Stock
10 mg	$56	In Stock	In Stock
25 mg	$92	In Stock	-
50 mg	$133	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$66	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.67%

Appearance:solid

Color:White

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Naloxegol oxalate AI Summary

Naloxegol oxalate exhibits antiviral activity by targeting SARS-CoV-2. Specifically, it inhibits SARS-CoV-2-induced cytotoxicity in Caco-2 cells with a 14.12% inhibition rate at a concentration of 10 µM after 48 hours. The compound also demonstrates an inhibitory activity of 13.22% on the SARS-CoV-2 3CL-Pro protease at 20 µM, indicating moderate inhibition of this crucial viral protease. However, its effect on VERO-6 cells shows a minimal inhibition rate of -0.16% at 10 µM after the same exposure period. These mixed results suggest that Naloxegol oxalate has varying efficacy depending on the cell line used..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Naloxegol oxalate (NKTR-118) is a peripherally-selective opioid antagonist for the treatment of opioid-induced constipation.
Synonyms	NKTR-118 oxalate, NKTR118 oxalate, AZ-13337019 oxalate, AZ 13337019 oxalate

Chemical Properties

Molecular Weight	741.83
Formula	C₃₆H₅₅NO₁₅
Cas No.	1354744-91-4
Smiles	COCCOCCOCCOCCOCCOCCOCCO[C@H]1CC[C@]2([C@H]3Cc4c5[C@]2([C@H]1Oc5c(cc4)O)CCN3CC=C)O.C(=O)(C(=O)O)O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (67.4 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.7 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3480 mL	6.7401 mL	13.4802 mL	67.4009 mL
5 mM	0.2696 mL	1.3480 mL	2.6960 mL	13.4802 mL
10 mM	0.1348 mL	0.6740 mL	1.3480 mL	6.7401 mL
20 mM	0.0674 mL	0.3370 mL	0.6740 mL	3.3700 mL
50 mM	0.0270 mL	0.1348 mL	0.2696 mL	1.3480 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc