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Ascrinvacumab (PF-03446962) is a highly humanized IgG2 monoclonal antibody against ALK-1. Ascrinvacumab has a Kd value of 7 nM for human ALK1. Ascrinvacumab has an inhibitory effect on TGF-β and can be used to study hepatocellular carcinoma (HCC).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 247.00 | |
5 mg | In stock | $ 647.00 | |
10 mg | In stock | $ 987.00 |
Description | Ascrinvacumab (PF-03446962) is a highly humanized IgG2 monoclonal antibody against ALK-1. Ascrinvacumab has a Kd value of 7 nM for human ALK1. Ascrinvacumab has an inhibitory effect on TGF-β and can be used to study hepatocellular carcinoma (HCC). |
Targets&IC50 | ALK1 (human):7 nM(Kd) |
In vitro |
Ascrinvacumab binds to human ALK1 with a Kd value of 7 nM[1]. In a 30-minute treatment, Ascrinvacumab blocks the response induced by BMP9 and FCS, alleviating BMP9-induced Smad1 phosphorylation intensity and duration[1]. At concentrations ranging from 0.01 to 10 μg/mL for 2 hours, Ascrinvacumab inhibits the binding of BMP9 to ALK1[1]. At 40 μg/mL for 2 hours, Ascrinvacumab effectively inhibits endothelial sprouting in human umbilical vein endothelial cells (HUVECs)[1]. |
In vivo | In a mouse xenograft tumor model, the combination of Ascrinvacumab with bevacizumab (anti-VEGF) reduces human vascular density and enhances the anti-tumor efficacy[1]. |
Synonyms | PF-03446962 |
Molecular Weight | N/A |
CAS No. | 1463459-96-2 |
store at low temperature
store at -80°C
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Ascrinvacumab 1463459-96-2 Angiogenesis Stem Cells Tyrosine Kinase/Adaptors ALK TGF-beta/Smad PF 03446962 PF03446962 PF-03446962 inhibitor inhibit