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1,4-Naphthoquinone

Name: 1,4-Naphthoquinone
Brand: TargetMol
SKU: T7048
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T7048Cas No. 130-15-4

Alias α-Naphthoquinone, P-Naphthoquinone, para-naphthoquinone, Naphthalene-1,4-Dione

1,4-Naphthoquinone (P-Naphthoquinone) was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities[2]. It was also used to inhibit the acetyltransferase activity[1].

1,4-Naphthoquinone

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Purity: 99.56%

Catalog No. T7048Alias α-Naphthoquinone, P-Naphthoquinone, para-naphthoquinone, Naphthalene-1,4-DioneCas No. 130-15-4

1,4-Naphthoquinone (P-Naphthoquinone) was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities[2]. It was also used to inhibit the acetyltransferase activity[1].

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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Batch Information

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Purity:99.56%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

1,4-Naphthoquinone AI Summary

1,4-Naphthoquinone exhibits a variety of bioactivities and inhibitory effects across multiple biological targets. It inhibits topoisomerase I with a minimal inhibitory concentration (MIC) greater than 500,000.0 nM and topoisomerase 2 ATPase domain with a 56% inhibition rate at 25 μM. It effectively increases survival time in mice against ascitic sarcoma 180, showing an ED25 of 1.9 mg/kg, and exhibits acute toxicity with an LD50 of 5.5 mg/kg. The compound demonstrates significant vasorelaxation, inhibiting acetylcholine-induced relaxation in rat aorta with an EC50 of 127.0 nM and an Emax of 98.0%. Furthermore, it shows protease inhibitory activity with IC50 values of 21,000.0 nM and 29,000.0 nM against HRV 3Cpro and papain, respectively, as well as 76.0% inhibition against papain. It has notable antiproliferative and cytotoxic effects against various cancer cell lines including murine leukemia, human lung carcinoma, colon carcinoma, melanoma, A2780, MG63, HepG2, MCF7, HT-29, MDA-MB-231, DU145, HCT116, SKOV3, and A549, with IC50 values ranging from 2,300.0 nM to greater than 25,000.0 nM depending on the cell line. 1,4-Naphthoquinone exhibits antimycobacterial activity, with a MIC of 1.0 μg/mL against Mycobacterium tuberculosis H37Rv and an IC50 of 1.2 μg/mL for cytotoxicity against Vero cells. It inhibits IDO1 (IC50 = 460.0 nM), MEK1 (IC50 = 380.0 nM), histone methyltransferases GLP (IC50 = 14,000.0 nM) and G9a (IC50 = 2,000.0 nM), recombinant Clostridium botulinum neurotoxin serotype A, recombinant AKT1, human recombinant MAO-A and MAO-B, and the human recombinant Pin1 enzyme. Additionally, the compound exhibits binding and inhibition of Mycobacterium tuberculosis Rv1284 (76.6% activity reduction at 25 μM) and N-terminal Hi-tagged Rv3588c (94.8% activity reduction at 25 μM). It demonstrates neuroprotective properties in mouse HT22 cells, with a therapeutic index (TI) of 12.0 and exhibits glutathione reactivity (20.0% to 47.0%). Finally, 1,4-Naphthoquinone inhibits SARS-CoV-2 main protease with an IC50 of 129.77 nM, and has antiviral activity against SARS-CoV-2 in Vero-6 cells with IC50 values greater than 20,000.0 nM. These diverse bioactivities and inhibitory effects make 1,4-Naphthoquinone a multifaceted candidate for further pharmacological and therapeutic evaluations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1,4-Naphthoquinone (P-Naphthoquinone) was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities[2]. It was also used to inhibit the acetyltransferase activity[1].
Synonyms	α-Naphthoquinone, P-Naphthoquinone, para-naphthoquinone, Naphthalene-1,4-Dione

Chemical Properties

Molecular Weight	158.15
Formula	C₁₀H₆O₂
Cas No.	130-15-4
Smiles	O=C1C=CC(=O)C2=C1C=CC=C2
Relative Density.	1.42

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (284.54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.65 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.3231 mL	31.6156 mL	63.2311 mL	316.1555 mL
5 mM	1.2646 mL	6.3231 mL	12.6462 mL	63.2311 mL
10 mM	0.6323 mL	3.1616 mL	6.3231 mL	31.6156 mL
20 mM	0.3162 mL	1.5808 mL	3.1616 mL	15.8078 mL
50 mM	0.1265 mL	0.6323 mL	1.2646 mL	6.3231 mL
100 mM	0.0632 mL	0.3162 mL	0.6323 mL	3.1616 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc