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Anti-CD50 Antibody (8S319)
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Catalog No. TMAY-00631
Alias intercellular adhesion molecule 3, ICAM-R, ICAM-3, CDW50, CD50
Anti-CD50 Antibody (8S319) is a Rabbit antibody targeting CD50. Anti-CD50 Antibody (8S319) can be used in IHC-P.
Anti-CD50 Antibody (8S319)
Anti-CD50 Antibody (8S319)
😃Good
Catalog No. TMAY-00631Alias intercellular adhesion molecule 3, ICAM-R, ICAM-3, CDW50, CD50
Anti-CD50 Antibody (8S319) is a Rabbit antibody targeting CD50. Anti-CD50 Antibody (8S319) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD50 Antibody (8S319) is a Rabbit antibody targeting CD50. Anti-CD50 Antibody (8S319) can be used in IHC-P. |
| Alias | intercellular adhesion molecule 3, ICAM-R, ICAM-3, CDW50, CD50 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 8S319 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human ICAM3 in human tonsil with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human ICAM3 in human spleen with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD50 / ICAM-3 (rh CD50 / ICAM-3; TMPY-01430; CAA49369.1; Met1-His485). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The protein ICAM-3, also known as CD50, is a member of the intercellular adhesion molecule (ICAM) family consisting of three members. It is a DC-SIGN ligand that is constitutively expressed on resting leukocytes and is thus an important molecule for the first immune response. ICAM-3 comprises five immunoglobulin-like domains and binds LFA-1 through its two N-terminal domains. It functions not only as an adhesion molecule but also as a potent signaling molecule. ICAM-3 binds to LFA-1 on antigen-presenting cells (APC) stabilizing the T cell-APC interaction, facilitating signaling through the CD3/TCR complex. However, recent evidence using cultured and transformed T cells suggests ICAM-3 may also function in signaling. It has been reported that the CD50 molecule can play a role in developing functionally mature T lymphocytes and its expression increases during the maturation process of T lymphocytes. Also, the interactions of ICAM-3 and LFA-1 facilitate HIV-1- induced virological synapse formation between T cells. ICAM-3 is associated with an increase in cellular radio-resistance and cancer cell proliferation. It could be considered as a candidate for anti-cancer drug development and as a cancer diagnostic marker. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human CD50 / ICAM-3 protein (TMPY-01430) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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