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Felbinac

Name: Felbinac
Brand: TargetMol
SKU: T0888
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0888Cas No. 5728-52-9

Alias Dapson, 4-Biphenylacetic acid

Felbinac (Dapson), a topical medicine, is an active metabolite of fenbufen. It is belonging to the family of medicines known as non-steroidal anti-inflammatory drugs (NSAIDs) of the arylpropionic acid class, which is used to treat muscle arthritis and inflammation.

Felbinac

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Purity: 99.47%

Catalog No. T0888Alias Dapson, 4-Biphenylacetic acidCas No. 5728-52-9

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$42	In Stock	In Stock
1 g	$50	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.47%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Felbinac AI Summary

Felbinac exhibits a rapid absorption profile in rats, achieving maximum plasma concentration (Cmax) of 32508.83 nM within 0.5 hours (Tmax = 0.5 hr) and a mean residence time (MRT) of 6.6 hours. It demonstrates oral bioavailability in rats at 18.1% (F = 18.1%). The compound also shows notable bioactivities such as antioxidant and anti-inflammatory effects, as well as analgesic activity in animal models. For instance, it reduces myeloperoxidase, superoxide dismutase, catalase activities, and lipid peroxidation in rats' stomachs and alleviates carrageenan-induced paw edema in Sprague-Dawley rats. Moreover, Felbinac exhibits broad-spectrum bioactivities: - It acts as a modulator of Lamin A Splicing (potency: 2511.9 nM) and an agonist of the Thyroid Stimulating Hormone Receptor (potency: 5011.9 nM). - It activates intracellular cAMP concentrations in Parental HEK 293 cells by targeting the Thyroid Stimulating Hormone Receptor (potency: 5011.9 nM). - It demonstrates dual cytoprotective action in a Cell Model of Huntington (potency: 0.0501 nM) and inhibitory activity against Human alpha-Glucosidase (potency: 12589.3 nM). - It shows activity against Ebola Virus entry in screening assays with AC50 values ranging from 25.12 uM to 44668.4 nM. - It inhibits firefly luciferase and TDP-43 with potencies of 30131.3 nM and 35481.3 nM, respectively. - It acts as a cyclooxygenase COX-1 enzyme inhibitor (IC50: 894.0 nM) and inhibits human MRP4 activity in uptake assays (IC50: 8200.0 nM). Regarding antiviral activity, Felbinac shows limited effect against SARS-CoV-2 in multiple assays, including a low inhibition index (0.2263) in Vero E6 cells and an inhibition rate of 4.64% in Caco-2 cells. The compound exhibits an IC50 value greater than 20000.0 nM against SARS-CoV-2 in VERO-6 cells but shows inhibitory effects against the 3CL-Pro protease with an inhibition rate of 8.275% at 20 µM. Finally, Felbinac exhibits minor inhibitory effects on human HDAC6 enzyme activity, with 10.58% inhibition using a commercial peptide substrate, but lesser inhibition in custom peptide assays. Its binding affinity and receptor interactions suggest broad, albeit generally weak, bioactivities that require further exploration to fully characterize its therapeutic potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Felbinac (Dapson), a topical medicine, is an active metabolite of fenbufen. It is belonging to the family of medicines known as non-steroidal anti-inflammatory drugs (NSAIDs) of the arylpropionic acid class, which is used to treat muscle arthritis and inflammation.
Targets&IC50	COX-2:976 nM, COX-1:865.68 nM
Synonyms	Dapson, 4-Biphenylacetic acid

Chemical Properties

Molecular Weight	212.24
Formula	C₁₄H₁₂O₂
Cas No.	5728-52-9
Smiles	OC(=O)CC1=CC=C(C=C1)C1=CC=CC=C1
Relative Density.	1.165 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (141.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7116 mL	23.5582 mL	47.1165 mL	235.5824 mL
5 mM	0.9423 mL	4.7116 mL	9.4233 mL	47.1165 mL
10 mM	0.4712 mL	2.3558 mL	4.7116 mL	23.5582 mL
20 mM	0.2356 mL	1.1779 mL	2.3558 mL	11.7791 mL
50 mM	0.0942 mL	0.4712 mL	0.9423 mL	4.7116 mL
100 mM	0.0471 mL	0.2356 mL	0.4712 mL	2.3558 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc