Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental autoimmune encephalomyelitis. Isogarcinol inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 μg/ml, respectively) through cell cycle arrest and apoptosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | 35 days | $ 98.00 | |
5 mg | 35 days | $ 443.00 | |
10 mg | 35 days | $ 780.00 | |
25 mg | 35 days | $ 1,700.00 |
Description | Isogarcinol is a natural polyisoprenylated benzophenone first isolated from plant species in the genus Garcinia. It has immunosuppressant actions, inhibiting the protein phosphatase calcineurin (IC50 = 36 μM) and suppressing the proliferation of T cells. Oral administration of isogarcinol in mice decreases delayed type hypersensitivity, prolongs graft survival in allogeneic skin transplants, suppresses inflammation in collagen-induced arthritis, and reduces clinical symptoms in experimental autoimmune encephalomyelitis. Isogarcinol inhibits the proliferation of HL-60 and PC-3 cancer cells (IC50s = 4 and 8 μg/ml, respectively) through cell cycle arrest and apoptosis. |
Molecular Weight | 602.8 |
Formula | C38H50O6 |
CAS No. | 71117-97-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 25 mg/mL
Ethanol: 20 mg/mL
DMSO:PBS (pH 7.2) (1:10): 0.1 mg/mL
DMSO: 25 mg/mL
You can also refer to dose conversion for different animals. More
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Isogarcinol 71117-97-0 inhibitor inhibit