IL-23 P19/IL23A Protein, Human, Recombinant (hFc)

IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1, the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Pack Size	Availability	Price/USD
50 μg	In stock	$ 245.00
100 μg	5 days	$ 416.00
200 μg	5 days	$ 704.00
500 μg	5 days	$ 1,410.00

Pack Size

Availability

Price/USD

Quantity

50 μg

In stock

$ 245.00

100 μg

5 days

$ 416.00

200 μg

5 days

$ 704.00

500 μg

5 days

$ 1,410.00

Biological Information

Testing in progress

Description

Species	Human
Expression System	HEK293
Tag	hFc
Accession Number	Q9NPF7
Synonyms	IL-23A, IL-23, interleukin 23, alpha subunit p19, SGRF, IL23P19, P19, interleukin 23, α subunit p19
Construction	A DNA sequence encoding the human IL23A (NP_057668.1) (Met1-Pro189) was expressed with the Fc region of human IgG1 at the C-terminus.
Protein Purity	> 85 % as determined by SDS-PAGE.
Molecular Weight	Approxiamtely 45.4 kDa

Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method.
Formulation	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution	A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
Stability & Storage	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Research Background	IL-23, which is mainly secreted by antigen-presenting cells, is a member of the IL-12 family, which includes IL-12, IL-27, and IL-35. IL-23 is a heterodimeric cytokine, comprised of a unique p19 subunit and p4 subunit, the latter of which is shared with IL-12. The receptor for IL-23 consists of IL-23R and IL-12Rβ1, the latter of which is also characteristic of IL-12. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy